TY - JOUR
T1 - Alpha-galactosylceramide (αgalcer) enhances vaccine-induced protection in a model of ricin intoxication
AU - Yates, Jennifer L.
AU - Leadbetter, Elizabeth
AU - Mantis, Nicholas J.
N1 - Publisher Copyright:
© 2018 Taylor & Francis.
PY - 2018
Y1 - 2018
N2 - Alpha-galactosylceramide (αGalCer) is a glycolipid derived from a marine sponge that is a potent activator of both mouse and human invariant natural killer T (iNKT) cells. For that reason, αGalCer is a promising vaccine adjuvant that has been shown to improve both humoral and cellular immunity when co-administered with various vaccines, including candidate vaccines for biodefense. In the current study, we tested the effectiveness of αGalCer as an adjuvant for the clinically-relevant ricin toxin subunit vaccine, RiVax. αGalCer had a potent adjuvant effect, as shown by a rapid onset of anti-ricin IgG titers, accelerated development of serum toxin-neutralizing activity, and enhanced protection from lethal ricin challenge in a mouse model. These results underscore the potential of αGalCer to augment the protective immune response to a vaccine designed to counteract ricin toxin, a fast-acting biothreat agent.
AB - Alpha-galactosylceramide (αGalCer) is a glycolipid derived from a marine sponge that is a potent activator of both mouse and human invariant natural killer T (iNKT) cells. For that reason, αGalCer is a promising vaccine adjuvant that has been shown to improve both humoral and cellular immunity when co-administered with various vaccines, including candidate vaccines for biodefense. In the current study, we tested the effectiveness of αGalCer as an adjuvant for the clinically-relevant ricin toxin subunit vaccine, RiVax. αGalCer had a potent adjuvant effect, as shown by a rapid onset of anti-ricin IgG titers, accelerated development of serum toxin-neutralizing activity, and enhanced protection from lethal ricin challenge in a mouse model. These results underscore the potential of αGalCer to augment the protective immune response to a vaccine designed to counteract ricin toxin, a fast-acting biothreat agent.
KW - B cell epitope
KW - Biodefense
KW - Monoclonal antibodies
KW - Toxin
UR - http://www.scopus.com/inward/record.url?scp=85059797218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059797218&partnerID=8YFLogxK
U2 - 10.1080/21645515.2018.1461299
DO - 10.1080/21645515.2018.1461299
M3 - Article
C2 - 29617191
AN - SCOPUS:85059797218
SN - 2164-5515
VL - 14
SP - 2053
EP - 2057
JO - Human Vaccines and Immunotherapeutics
JF - Human Vaccines and Immunotherapeutics
IS - 8
ER -