Abstract
The aim of this study was to determine whether an Aloe vera extract would prevent aspirin-induced acute gastric mucosal injury in rats. We also examined whether the extract had any effects on gastric mucosal prostaglandin E2 (PGE2), an established gastro-protective factor that is modulated by Aloe vera extracts in various experimental wound healing models. There were no gastric mucosal lesions in rats treated with normal saline and vehicle or the extract and vehicle. Aspirin caused significant gastric mucosal injury in rats pre-treated with normal saline alone. Pre-treatment with an Aloe vera extract reduced aspirin-induced injury by 70% p < 0.005 versus saline pre-treatment). Aspirin, a well-known inhibitor of PG synthesis, reduced PGE2 formation in rat stomachs. Furthermore, pre-treatment with either extract or heat-inactivated extract failed to alter the aspirin-induced reduction in PGE2 formation in rat stomachs. Taken together, our data suggest that Aloe vera extract has gastro-protective properties and that this is not directly related to PG formation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 765-766 |
| Number of pages | 2 |
| Journal | Medical Science Research |
| Volume | 25 |
| Issue number | 11 |
| State | Published - Dec 8 1997 |
Keywords
- Aloe vera
- Aspirin
- Gastric injury
- Prostaglandin E
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)