The liver enzyme phenylalanine hydroxylase is responsible for conversion of excess phenylalanine in the diet to tyrosine. Phenylalanine hydroxylase is activated by phenylalanine; this activation is inhibited by the physiological reducing substrate tetrahydrobiopterin. Phosphorylation of Ser16 lowers the concentration of phenylalanine for activation. This review discusses the present understanding of the molecular details of the allosteric regulation of the enzyme.
|Original language||English (US)|
|Number of pages||8|
|Journal||Archives of Biochemistry and Biophysics|
|State||Published - Mar 15 2012|
- Phenylalanine hydroxylase
ASJC Scopus subject areas
- Molecular Biology