Allogeneic Stem Cell Transplantation in Myelofibrosis

Tania Jain, Ruben Mesa, Jeanne M. Palmer

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Myeloproliferative neoplasm (MPN) is a category in the World Health Organization classification of myeloid tumors. BCR-ABL1–negative MPN is a subcategory that includes primary myelofibrosis (MF), post–essential thrombocythemia MF, and post–polycythemia vera MF. These disorders are characterized by stem cell–derived clonal myeloproliferation. Clinically, these diseases present with anemia and splenomegaly and significant constitutional symptoms such as severe fatigue, symptoms associated with an enlarged spleen and liver, pruritus, fevers, night sweats, and bone pain. Multiple treatment options may provide symptom relief and improved survival; however, allogeneic stem cell transplantation (HCT) remains the only potentially curative option. The decision for a transplant is based on patient prognosis, age, comorbidities, and functional status. This review describes the recent data on various peritransplantation factors and their effect on outcomes of patients with MF and new therapeutic areas, such as the use and timing of Janus kinase inhibitors with HCT and gives overall conclusions from the available data in the published literature.

Original languageEnglish (US)
Pages (from-to)1429-1436
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Keywords

  • Allogeneic stem cell transplantation
  • Myelofibrosis

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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