Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome

M. J. Lechowicz, H. M. Lazarus, J. Carreras, G. G. Laport, C. S. Cutler, P. H. Wiernik, G. A. Hale, D. Maharaj, R. P. Gale, P. A. Rowlings, C. O. Freytes, A. M. Miller, J. M. Vose, R. T. Maziarz, S. Montoto, D. G. Maloney, P. N. Hari

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36 Scopus citations

Abstract

We describe outcomes after allogeneic hematopoietic cell transplantation (HCT) for mycosis fungoides and Sezary syndrome (MF/SS). Outcomes of 129 subjects with MF/SS reported to the Center for the International Blood and Marrow Transplant from 2000-2009. Median time from diagnosis to transplant was 30 (4-206) months and most subjects were with multiply relapsed/ refractory disease. The majority (64%) received non-myeloablative conditioning (NST) or reduced intensity conditioning (RIC). NST/RIC recipients were older in age compared with myeloablative recipients (median age 51 vs 44 years, P=0.005) and transplanted in recent years. Non-relapse mortality (NRM) at 1 and 5 years was 19% (95% confidence interval (CI) 12-27%) and 22% (95% CI 15-31%), respectively. Risk of disease progression was 50% (95% CI 41-60%) at 1 year and 61% (95% CI 50-71%) at 5 years. PFS at 1 and 5 years was 31% (95% CI 22-40%) and 17% (95% CI 9-26%), respectively. OS at 1 and 5 years was 54% (95% CI 45-63%) and 32% (95% CI 22-44%), respectively. Allogeneic HCT in MF/SS results in 5-year survival in approximately one-third of patients and of those, half remain disease-free.

Original languageEnglish (US)
Pages (from-to)1360-1365
Number of pages6
JournalBone Marrow Transplantation
Volume49
Issue number11
DOIs
StatePublished - Nov 13 2014

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ASJC Scopus subject areas

  • Hematology
  • Transplantation

Cite this

Lechowicz, M. J., Lazarus, H. M., Carreras, J., Laport, G. G., Cutler, C. S., Wiernik, P. H., Hale, G. A., Maharaj, D., Gale, R. P., Rowlings, P. A., Freytes, C. O., Miller, A. M., Vose, J. M., Maziarz, R. T., Montoto, S., Maloney, D. G., & Hari, P. N. (2014). Allogeneic hematopoietic cell transplantation for mycosis fungoides and Sezary syndrome. Bone Marrow Transplantation, 49(11), 1360-1365. https://doi.org/10.1038/bmt.2014.161