Allergic broncho-pulmonary aspergillosis

Divya Seth, Pavadee Poowuttikul, Milind Pansare, Ibrahim Abdulhamid, Deepak Kamat

Research output: Contribution to journalArticlepeer-review


Allergic broncho-pulmonary aspergillosis (ABPA) is an immunologically mediated lung disease that usually occurs in people with a diagnosis of asthma or cystic fibrosis. It is a non-invasive lung disease caused by colonization of the airways with Aspergillus fumigatus. In people who are susceptible, Aspergillus leads to an exaggerated immune response and ulti-mately pulmonary inflammation and lung damage. Patients with ABPA typically present with poorly controlled asthma, recurrent pulmonary infiltrates, and bronchiectasis. Diagnosis of ABPA is established based on a combination of clinical manifestations as well as laboratory and radiological evaluations. Delay in diagnosis can result in airway destruction and pulmonary fibrosis, which may result in significant morbidity and mortality. This article discusses the clinical characteristics, diagnosis, and management of patients with ABPA. It aims to serve as a tool for pediatricians to aid in early recognition of this debilitating disease and consider referral, facilitating early diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)e214-e221
JournalPediatric annals
Issue number5
StatePublished - May 2021

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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