ALE meta-analysis workfl ows via the BrainMap database: Progress towards a probabilistic functional brain atlas

Angela R. Laird, Simon B. Eickhoff, Florian Kurth, Peter M. Fox, Angela M. Uecker, Jessica A. Turner, Jennifer L. Robinson, Jack L Lancaster, Peter T Fox

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

With the ever-increasing number of studies in human functional brain mapping, an abundance of data has been generated that is ready to be synthesized and modeled on a large scale. The BrainMap database archives peak coordinates from published neuroimaging studies, along with the corresponding metadata that summarize the experimental design. BrainMap was designed to facilitate quantitative meta-analysis of neuroimaging results reported in the literature and supports the use of the activation likelihood estimation (ALE) method. In this paper, we present a discussion of the potential analyses that are possible using the BrainMap database and coordinate-based ALE meta-analyses, along with some examples of how these tools can be applied to create a probabilistic atlas and ontological system of describing function-structure correspondences.

Original languageEnglish (US)
Article number23
JournalFrontiers in Neuroinformatics
Volume3
Issue numberJUL
DOIs
StatePublished - Jul 9 2009

Fingerprint

Neuroimaging
Atlases
Meta-Analysis
Brain
Brain mapping
Chemical activation
Databases
Brain Mapping
Describing functions
Metadata
Design of experiments
Research Design

Keywords

  • Activation likelihood estimation
  • BrainMap
  • Functional atlas
  • Meta-analysis
  • Ontology

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biomedical Engineering
  • Computer Science Applications

Cite this

ALE meta-analysis workfl ows via the BrainMap database : Progress towards a probabilistic functional brain atlas. / Laird, Angela R.; Eickhoff, Simon B.; Kurth, Florian; Fox, Peter M.; Uecker, Angela M.; Turner, Jessica A.; Robinson, Jennifer L.; Lancaster, Jack L; Fox, Peter T.

In: Frontiers in Neuroinformatics, Vol. 3, No. JUL, 23, 09.07.2009.

Research output: Contribution to journalArticle

Laird, AR, Eickhoff, SB, Kurth, F, Fox, PM, Uecker, AM, Turner, JA, Robinson, JL, Lancaster, JL & Fox, PT 2009, 'ALE meta-analysis workfl ows via the BrainMap database: Progress towards a probabilistic functional brain atlas', Frontiers in Neuroinformatics, vol. 3, no. JUL, 23. https://doi.org/10.3389/neuro.11.023.2009
Laird, Angela R. ; Eickhoff, Simon B. ; Kurth, Florian ; Fox, Peter M. ; Uecker, Angela M. ; Turner, Jessica A. ; Robinson, Jennifer L. ; Lancaster, Jack L ; Fox, Peter T. / ALE meta-analysis workfl ows via the BrainMap database : Progress towards a probabilistic functional brain atlas. In: Frontiers in Neuroinformatics. 2009 ; Vol. 3, No. JUL.
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