TY - JOUR
T1 - AKI on CKD
T2 - heightened injury, suppressed repair, and the underlying mechanisms
AU - He, Liyu
AU - Wei, Qingqing
AU - Liu, Jing
AU - Yi, Mixuan
AU - Liu, Yu
AU - Liu, Hong
AU - Sun, Lin
AU - Peng, Youming
AU - Liu, Fuyou
AU - Venkatachalam, Manjeri A.
AU - Dong, Zheng
N1 - Publisher Copyright:
© 2017 International Society of Nephrology
PY - 2017/11
Y1 - 2017/11
N2 - Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very limited. Nonetheless, AKI, when occurring in patients with CKD, is known to be more severe and difficult to recover. CKD is associated with significant changes in cell signaling in kidney tissues, including the activation of transforming growth factor-β, p53, hypoxia-inducible factor, and major developmental pathways. At the cellular level, CKD is characterized by mitochondrial dysfunction, oxidative stress, and aberrant autophagy. At the tissue level, CKD is characterized by chronic inflammation and vascular dysfunction. These pathologic changes may contribute to the heightened sensitivity of, and nonrecovery from, AKI in patients with CKD.
AB - Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected. Although AKI-to-CKD transition has been intensively studied, the information of AKI on CKD is very limited. Nonetheless, AKI, when occurring in patients with CKD, is known to be more severe and difficult to recover. CKD is associated with significant changes in cell signaling in kidney tissues, including the activation of transforming growth factor-β, p53, hypoxia-inducible factor, and major developmental pathways. At the cellular level, CKD is characterized by mitochondrial dysfunction, oxidative stress, and aberrant autophagy. At the tissue level, CKD is characterized by chronic inflammation and vascular dysfunction. These pathologic changes may contribute to the heightened sensitivity of, and nonrecovery from, AKI in patients with CKD.
KW - acute kidney injury
KW - cell signaling
KW - chronic kidney disease
KW - fibrosis
KW - inflammation
KW - mitochondria
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U2 - 10.1016/j.kint.2017.06.030
DO - 10.1016/j.kint.2017.06.030
M3 - Review article
C2 - 28890325
AN - SCOPUS:85031018816
SN - 0085-2538
VL - 92
SP - 1071
EP - 1083
JO - Kidney international
JF - Kidney international
IS - 5
ER -