Airway Epithelial Cell-Derived Colony Stimulating Factor-1 Promotes Allergen Sensitization

Hyung Geun Moon, Seung jae Kim, Jong Jin Jeong, Seon Sook Han, Nizar N. Jarjour, Hyun Lee, Sherry L. Abboud-Werner, Sangwoon Chung, Hak Soo Choi, Viswanathan Natarajan, Steven J. Ackerman, John W. Christman, Gye Young Park

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Airway epithelial cells (AECs) secrete innate immune cytokines that regulate adaptive immune effector cells. In allergen-sensitized humans and mice, the airway and alveolar microenvironment is enriched with colony stimulating factor-1 (CSF1) in response to allergen exposure. In this study we found that AEC-derived CSF1 had a critical role in the production of allergen reactive-IgE production. Furthermore, spatiotemporally secreted CSF1 regulated the recruitment of alveolar dendritic cells (DCs) and enhanced the migration of conventional DC2s (cDC2s) to the draining lymph node in an interferon regulatory factor 4 (IRF4)-dependent manner. CSF1 selectively upregulated the expression of the chemokine receptor CCR7 on the CSF1R + cDC2, but not the cDC1, population in response to allergen stimuli. Our data describe the functional specification of CSF1-dependent DC subsets that link the innate and adaptive immune responses in T helper 2 (Th2) cell-mediated allergic lung inflammation. Airway epithelial cells are the first line of defense against foreign antigens and influence the microenvironment of the lung by secreting bioactive mediators. Moon and colleagues demonstrate that airway epithelial cells regulate dendritic cells for trafficking aeroallergen and subsequent development of adaptive immune responses.

Original languageEnglish (US)
Pages (from-to)275-287.e5
JournalImmunity
Volume49
Issue number2
DOIs
StatePublished - Aug 21 2018

Keywords

  • CSF1
  • CSF1 receptor
  • CSF1R
  • IRF4
  • IgE
  • airway dendritic cells
  • airway epithelial cells
  • allergic sensitization
  • asthma
  • cDC2
  • colony stimulating factor 1
  • conventional dendritic cells type 2
  • immunoglobulin E
  • interferon regulatory factor 4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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