Aiding and abetting roles of NOX oxidases in cellular transformation

Karen Block, Yves Gorin

Research output: Contribution to journalReview articlepeer-review

177 Scopus citations


NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.

Original languageEnglish (US)
Pages (from-to)627-637
Number of pages11
JournalNature Reviews Cancer
Issue number9
StatePublished - Sep 2012

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'Aiding and abetting roles of NOX oxidases in cellular transformation'. Together they form a unique fingerprint.

Cite this