Aiding and abetting roles of NOX oxidases in cellular transformation

Karen Block, Yves Gorin

Research output: Contribution to journalArticle

144 Citations (Scopus)

Abstract

NADPH oxidases of the NADPH oxidase (NOX) family are dedicated reactive oxygen species-generating enzymes that broadly and specifically regulate redox-sensitive signalling pathways that are involved in cancer development and progression. They act at specific cellular membranes and microdomains through the activation of oncogenes and the inactivation of tumour suppressor proteins. In this Review, we discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS, and the biological role of NOX oxidases in the aetiology of cancer.

Original languageEnglish (US)
Pages (from-to)627-637
Number of pages11
JournalNature Reviews Cancer
Volume12
Issue number9
DOIs
StatePublished - Sep 2012

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NADPH Oxidase
Oxidoreductases
Oxidation-Reduction
Membrane Microdomains
Tumor Suppressor Proteins
Oncogenes
Reactive Oxygen Species
Neoplasms
Enzymes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Aiding and abetting roles of NOX oxidases in cellular transformation. / Block, Karen; Gorin, Yves.

In: Nature Reviews Cancer, Vol. 12, No. 9, 09.2012, p. 627-637.

Research output: Contribution to journalArticle

Block, Karen ; Gorin, Yves. / Aiding and abetting roles of NOX oxidases in cellular transformation. In: Nature Reviews Cancer. 2012 ; Vol. 12, No. 9. pp. 627-637.
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