Agmatine enhances caloric intake and dietary carbohydrate preference in satiated rats

Anand Prasad, Chandan Prasad

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Agmatine is a decarboxylated metabolite of arginine endogenous to the brain. In vitro, agmatine inhibits binding of clonidine to α2-adrenergic and imidazoline receptors. We have shown that acute administration of agmatine increases caloric intake and dietary carbohydrate preference in satiated rats. In contrast, agmatine does not modulate caloric intake in hungry rats. Furthermore, repeated administration of high doses of agmatine does not decrease its ability to stimulate appetite.

Original languageEnglish (US)
Pages (from-to)1187-1189
Number of pages3
JournalPhysiology and Behavior
Volume60
Issue number4
DOIs
StatePublished - Oct 1996
Externally publishedYes

Keywords

  • Agmatine
  • Appetite
  • Arginine metabolism
  • Carbohydrate preference
  • α-Adrenergic receptor

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

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