Agmatine enhances caloric intake and dietary carbohydrate preference in satiated rats

Anand Prasad; Chandan Prasad

doi:10.1016/0031-9384(96)00151-5

Agmatine enhances caloric intake and dietary carbohydrate preference in satiated rats

Anand Prasad, Chandan Prasad

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Agmatine is a decarboxylated metabolite of arginine endogenous to the brain. In vitro, agmatine inhibits binding of clonidine to α₂-adrenergic and imidazoline receptors. We have shown that acute administration of agmatine increases caloric intake and dietary carbohydrate preference in satiated rats. In contrast, agmatine does not modulate caloric intake in hungry rats. Furthermore, repeated administration of high doses of agmatine does not decrease its ability to stimulate appetite.

Original language	English (US)
Pages (from-to)	1187-1189
Number of pages	3
Journal	Physiology and Behavior
Volume	60
Issue number	4
DOIs	https://doi.org/10.1016/0031-9384(96)00151-5
State	Published - Oct 1996
Externally published	Yes

Keywords

Agmatine
Appetite
Arginine metabolism
Carbohydrate preference
α-Adrenergic receptor

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(96)00151-5

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abstract = "Agmatine is a decarboxylated metabolite of arginine endogenous to the brain. In vitro, agmatine inhibits binding of clonidine to α2-adrenergic and imidazoline receptors. We have shown that acute administration of agmatine increases caloric intake and dietary carbohydrate preference in satiated rats. In contrast, agmatine does not modulate caloric intake in hungry rats. Furthermore, repeated administration of high doses of agmatine does not decrease its ability to stimulate appetite.",

keywords = "Agmatine, Appetite, Arginine metabolism, Carbohydrate preference, α-Adrenergic receptor",

author = "Anand Prasad and Chandan Prasad",

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AU - Prasad, Anand

AU - Prasad, Chandan

PY - 1996/10

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AB - Agmatine is a decarboxylated metabolite of arginine endogenous to the brain. In vitro, agmatine inhibits binding of clonidine to α2-adrenergic and imidazoline receptors. We have shown that acute administration of agmatine increases caloric intake and dietary carbohydrate preference in satiated rats. In contrast, agmatine does not modulate caloric intake in hungry rats. Furthermore, repeated administration of high doses of agmatine does not decrease its ability to stimulate appetite.

KW - Agmatine

KW - Appetite

KW - Arginine metabolism

KW - Carbohydrate preference

KW - α-Adrenergic receptor

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JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 4

ER -

Agmatine enhances caloric intake and dietary carbohydrate preference in satiated rats

Abstract

Keywords

ASJC Scopus subject areas

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