Agmatine: A novel endogenous vasodilator substance

Yuqi Gao, Bulent Gumusel, Gabor Koves, Anand Prasad, Qingzhong Hao, Albert Hyman, Howard Lippton

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.

Original languageEnglish (US)
Pages (from-to)PL83-PL86
JournalLife Sciences
Volume57
Issue number8
DOIs
StatePublished - Jul 14 1995
Externally publishedYes

Keywords

  • agmatine
  • clonidine-displacing substance
  • vasodilation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Gao, Y., Gumusel, B., Koves, G., Prasad, A., Hao, Q., Hyman, A., & Lippton, H. (1995). Agmatine: A novel endogenous vasodilator substance. Life Sciences, 57(8), PL83-PL86. https://doi.org/10.1016/0024-3205(95)02011-7