Agmatine: A novel endogenous vasodilator substance

Yuqi Gao; Bulent Gumusel; Gabor Koves; Anand Prasad; Qingzhong Hao; Albert Hyman; Howard Lippton

doi:10.1016/0024-3205(95)02011-7

Agmatine: A novel endogenous vasodilator substance

Yuqi Gao, Bulent Gumusel, Gabor Koves, Anand Prasad, Qingzhong Hao, Albert Hyman, Howard Lippton

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.

Original language	English (US)
Pages (from-to)	PL83-PL86
Journal	Life Sciences
Volume	57
Issue number	8
DOIs	https://doi.org/10.1016/0024-3205(95)02011-7
State	Published - Jul 14 1995
Externally published	Yes

Keywords

agmatine
clonidine-displacing substance
vasodilation

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(95)02011-7

Cite this

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title = "Agmatine: A novel endogenous vasodilator substance",

abstract = "The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.",

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T2 - A novel endogenous vasodilator substance

AU - Gao, Yuqi

AU - Gumusel, Bulent

AU - Koves, Gabor

AU - Prasad, Anand

AU - Hao, Qingzhong

AU - Hyman, Albert

AU - Lippton, Howard

PY - 1995/7/14

Y1 - 1995/7/14

N2 - The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.

AB - The purpose of the study was to investigate the effects of agmatine, an endogenous clonidine-displacing substance (CDS), on systemic hemodynamics in the anesthetized rat. Bolus intravenous (i.v.) injections of agmatine decreased systemic arterial pressure (SAP) and systemic vascular resistance in a dose-dependent manner. The development of acute tachyphylaxis to the systemic vasodepressor response to agmatine did not induce cross-tachyphylaxis to the systemic vasodepressor responses to bradykinin, isoproterenol and nitroglycerin. The present data demonstrate agmatine, as a CDS and agonist for imidazoline (I) receptors, possesses marked systemic vasodilator activity in the rat. The present data suggest that activation of I receptors may represent a novel mechanism of vasodilation in vivo.

KW - agmatine

KW - clonidine-displacing substance

KW - vasodilation

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JO - Life Sciences

JF - Life Sciences

IS - 8

ER -

Agmatine: A novel endogenous vasodilator substance

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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