Aging research using the common marmoset: Focus on aging interventions

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Traditional animal models have been used to make seminal discoveries in biomedical research including a better understanding of the biology of the aging process. However, translation of these findings from laboratory to clinical populations has likely been hindered due to fundamental biological and physiological differences between common laboratory animals and humans. Non-human primates (NHP) may serve as an effective bridge towards translation, and short-lived NHP like the common marmoset offer many advantages as models for aging research. Here, we address these advantages and discuss what is currently understood about the changes in physiology and pathology that occur with age in the marmoset. In addition, we discuss how aging research might best utilize this model resource, and outline an ongoing study to address whether pharmaceutical intervention can slow aging in the marmoset. With this manuscript, we clarify how common marmosets might assist researchers in geroscience as a potential model for pre-clinical translation.

Original languageEnglish (US)
Pages (from-to)97-109
Number of pages13
JournalNutrition and Healthy Aging
Volume5
Issue number2
DOIs
StatePublished - Jan 1 2019

Keywords

  • Marmoset
  • longevity
  • mTOR
  • non-human primate
  • rapamycin
  • resilience

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Biochemistry
  • Nutrition and Dietetics

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