Abstract
The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α1 mRNA level was markedly decreased (86% suppression). In contrast, α1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.
Original language | English (US) |
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Pages (from-to) | 171-174 |
Number of pages | 4 |
Journal | European Journal of Pharmacology: Molecular Pharmacology |
Volume | 208 |
Issue number | 2 |
DOIs | |
State | Published - Oct 14 1991 |
Keywords
- GABA receptor binding
- GABA receptor subunits
- GABA receptors
- α GABA receptor subunit mRNA
ASJC Scopus subject areas
- Pharmacology