Aging reduces the mRNA of α1 GABAA receptor subunit in rat cerebral cortex

Molina C. Mhatre; Gabriel Fernandes; Maharaj K. Ticku

doi:10.1016/0922-4106(91)90068-S

Aging reduces the mRNA of α₁ GABA_A receptor subunit in rat cerebral cortex

Molina C. Mhatre, Gabriel Fernandes, Maharaj K. Ticku

Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABA_A receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [³⁵S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α₁ mRNA level was markedly decreased (86% suppression). In contrast, α₁ mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABA_A receptor in rat cerebral cortex.

Original language	English (US)
Pages (from-to)	171-174
Number of pages	4
Journal	European Journal of Pharmacology: Molecular Pharmacology
Volume	208
Issue number	2
DOIs	https://doi.org/10.1016/0922-4106(91)90068-S
State	Published - Oct 14 1991

Keywords

GABA receptor binding
GABA receptor subunits
GABA receptors
α GABA receptor subunit mRNA

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1016/0922-4106(91)90068-S

Cite this

@article{47dc14bedd994277a00716d13736c758,

title = "Aging reduces the mRNA of α1 GABAA receptor subunit in rat cerebral cortex",

abstract = "The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α1 mRNA level was markedly decreased (86% suppression). In contrast, α1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.",

keywords = "GABA receptor binding, GABA receptor subunits, GABA receptors, α GABA receptor subunit mRNA",

author = "Mhatre, {Molina C.} and Gabriel Fernandes and Ticku, {Maharaj K.}",

note = "Funding Information: The authorsw isl', to expresst hanksto Ms. Sadie Phillips for expert secretariaal ssistanceT.h is work was supportedin part by NIII grant NS15339a nd a subgranot f a GeriatricL eadershipA ca-demic Award (NIA No. AG00469).",

year = "1991",

month = oct,

day = "14",

doi = "10.1016/0922-4106(91)90068-S",

language = "English (US)",

volume = "208",

pages = "171--174",

journal = "European Journal of Pharmacology - Molecular Pharmacology Section",

issn = "0922-4106",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Aging reduces the mRNA of α1 GABAA receptor subunit in rat cerebral cortex

AU - Mhatre, Molina C.

AU - Fernandes, Gabriel

AU - Ticku, Maharaj K.

N1 - Funding Information: The authorsw isl', to expresst hanksto Ms. Sadie Phillips for expert secretariaal ssistanceT.h is work was supportedin part by NIII grant NS15339a nd a subgranot f a GeriatricL eadershipA ca-demic Award (NIA No. AG00469).

PY - 1991/10/14

Y1 - 1991/10/14

N2 - The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α1 mRNA level was markedly decreased (86% suppression). In contrast, α1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.

AB - The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α1 mRNA level was markedly decreased (86% suppression). In contrast, α1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.

KW - GABA receptor binding

KW - GABA receptor subunits

KW - GABA receptors

KW - α GABA receptor subunit mRNA

UR - http://www.scopus.com/inward/record.url?scp=0026070067&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026070067&partnerID=8YFLogxK

U2 - 10.1016/0922-4106(91)90068-S

DO - 10.1016/0922-4106(91)90068-S

M3 - Article

C2 - 1666053

AN - SCOPUS:0026070067

VL - 208

SP - 171

EP - 174

JO - European Journal of Pharmacology - Molecular Pharmacology Section

JF - European Journal of Pharmacology - Molecular Pharmacology Section

SN - 0922-4106

IS - 2

ER -