Abstract
The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α1 mRNA level was markedly decreased (86% suppression). In contrast, α1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 171-174 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology: Molecular Pharmacology |
| Volume | 208 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 14 1991 |
Keywords
- GABA receptor binding
- GABA receptor subunits
- GABA receptors
- α GABA receptor subunit mRNA
ASJC Scopus subject areas
- Pharmacology
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Mhatre, M. C., Fernandes, G., & Ticku, M. K. (1991). Aging reduces the mRNA of α1 GABAA receptor subunit in rat cerebral cortex. European Journal of Pharmacology: Molecular Pharmacology, 208(2), 171-174. https://doi.org/10.1016/0922-4106(91)90068-S