Aging reduces the mRNA of α1 GABAA receptor subunit in rat cerebral cortex

Molina C. Mhatre, Gabriel Fernandes, Maharaj K. Ticku

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

The effect of aging on the binding of ligands to the GABA, benzodiazepine and picrotoxin binding sites as well as α subunit mRNA level of GABAA receptor was investigated in cerebral cortex of male Fischer F-344 rats. In aged (730- to 770-day-old) rats, the binding of [35S]t-butylbicyclophosphorothionate (TBPS) was significantly reduced. Also, α1 mRNA level was markedly decreased (86% suppression). In contrast, α1 mRNA remained unchanged in cerebellum. These findings indicate a selective age-related structural change in GABAA receptor in rat cerebral cortex.

Original languageEnglish (US)
Pages (from-to)171-174
Number of pages4
JournalEuropean Journal of Pharmacology: Molecular Pharmacology
Volume208
Issue number2
DOIs
StatePublished - Oct 14 1991

Keywords

  • GABA receptor binding
  • GABA receptor subunits
  • GABA receptors
  • α GABA receptor subunit mRNA

ASJC Scopus subject areas

  • Pharmacology

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