Aging phenotypes of common marmosets (Callithrix jacchus)

Corinna N. Ross, Kenneth Davis, Georgina Dobek, Suzette D. Tardif

Research output: Contribution to journalArticle

48 Scopus citations

Abstract

Characterizing the phenotypic changes associated with aging in a short-lived primate is necessary in order to develop better translational models for human health, aging, and disease research. A population of conventionally housed marmoset monkeys was assessed to determine if phenotypes of body composition, hematology, and morphometrical measures were associated with age or risk of death. We found that the cause of mortality in older marmosets was more likely to be due to cardiac and chronic kidney disease than in younger marmosets. Older marmosets have decreased fat mass, morphometric measures, and serum albumin. Older marmosets are more likely to show a modified posture while at rest and this modified posture was significantly associated with an increased risk of imminent death. These assessments provide an initial definition of aged health in marmosets and a base for future translational aging research with this species.

Original languageEnglish (US)
Article number567143
JournalJournal of Aging Research
Volume2012
DOIs
StatePublished - Nov 7 2012

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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