Aging Endocrine and Metabolic Phenotypes Are Programmed by Mother's Age at Conception in a Sex-Dependent Fashion in the Rat

Elena Zambrano, Luis A. Reyes-Castro, Guadalupe L. Rodriguez-Gonzalez, Roberto Chavira, Peter W. Nathanielsz

Research output: Contribution to journalArticlepeer-review

Abstract

Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150, or 300 days' life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day mothers. Serum dehydroepiandrosterone:corticosterone was lowest in both sexes of offspring of 70- and 300-day mothers. Male and female fat depots were smaller in offspring of 150- than 70- and 90-day mothers. Insulin, glucose, and homeostatic model assessment were similar in all male offspring but higher in female offspring of 70-day mothers than other ages. We conclude, maternal age affects offspring aging in an offspring sex-dependent manner and merits consideration in designing and interpreting programming studies.

Original languageEnglish (US)
Pages (from-to)2304-2307
Number of pages4
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume75
Issue number12
DOIs
StatePublished - Dec 1 2020
Externally publishedYes

Keywords

  • Developmental programming
  • corticosterone
  • dehydroepiandrosterone
  • maternal age
  • metabolic age

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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