TY - JOUR
T1 - Aging Endocrine and Metabolic Phenotypes Are Programmed by Mother's Age at Conception in a Sex-Dependent Fashion in the Rat
AU - Zambrano, Elena
AU - Reyes-Castro, Luis A.
AU - Rodriguez-Gonzalez, Guadalupe L.
AU - Chavira, Roberto
AU - Nathanielsz, Peter W.
N1 - Funding Information:
This work was supported by CONACyT-48839 and the Newton Fund RCUK-CONACyT (Research Councils UK—Consejo Nacional de Ciencia y Tecnologia) I000/726/2016 FONCICYT/49/2016.
Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150, or 300 days' life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day mothers. Serum dehydroepiandrosterone:corticosterone was lowest in both sexes of offspring of 70- and 300-day mothers. Male and female fat depots were smaller in offspring of 150- than 70- and 90-day mothers. Insulin, glucose, and homeostatic model assessment were similar in all male offspring but higher in female offspring of 70-day mothers than other ages. We conclude, maternal age affects offspring aging in an offspring sex-dependent manner and merits consideration in designing and interpreting programming studies.
AB - Programming of offspring life-course health by maternal nutrition and stress are well studied. At postnatal day 850, we evaluated male and female steroid levels and metabolism in aged offspring of primigravid sister rats bred at 70, 90, 150, or 300 days' life. At 850 days life, male offspring corticosterone was similar regardless of maternal age. Female corticosterone was highest in offspring of 70- and 300-day mothers. Serum dehydroepiandrosterone:corticosterone was lowest in both sexes of offspring of 70- and 300-day mothers. Male and female fat depots were smaller in offspring of 150- than 70- and 90-day mothers. Insulin, glucose, and homeostatic model assessment were similar in all male offspring but higher in female offspring of 70-day mothers than other ages. We conclude, maternal age affects offspring aging in an offspring sex-dependent manner and merits consideration in designing and interpreting programming studies.
KW - Developmental programming
KW - corticosterone
KW - dehydroepiandrosterone
KW - maternal age
KW - metabolic age
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U2 - 10.1093/gerona/glaa067
DO - 10.1093/gerona/glaa067
M3 - Article
C2 - 32154556
AN - SCOPUS:85096152634
SN - 1079-5006
VL - 75
SP - 2304
EP - 2307
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 12
ER -