Aging and the pathogenic response to burn

Meenakshi Rani, Martin G. Schwacha

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Aging is an important and critical factor that contributes to the clinical outcome of burn patients. The very young and the elderly are more likely to succumb after major burn as compared to their adult counterparts. With the aging population, improved understanding of the mechanisms underlying age-associated complications after burns becomes even more demanding. It is widely accepted that elderly burn patients have significantly increased morbidity and mortality. Irrespective of the type of burn injury, the aged population shows slower recoveries and suffers more complications. Age-associated immune dysfunction, immunosenescence, may predispose the elderly burn patients to more infections, slower healing and/or to other complications. Furthermore, pre-existing, age-related medical conditions such as, pulmonary/cardiovascular dysfunctions and diabetes in the elderly are other important factors that contribute to their poorer outcomes after major burn. The present review describes the impact of aging on burn patients outcomes.

Original languageEnglish (US)
Pages (from-to)171-180
Number of pages10
JournalAging and Disease
Volume3
Issue number2
StatePublished - Jan 1 2012

Keywords

  • Aging
  • Burn
  • Immune
  • Infection
  • Pathophysiology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology

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