Aging and benzodiazepine binding in the rat cerebral cortex

C. C. Tsang; K. V. Speeg; G. R. Wilkinson

doi:10.1016/0024-3205(82)90570-7

Aging and benzodiazepine binding in the rat cerebral cortex

C. C. Tsang, K. V. Speeg, G. R. Wilkinson

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The specific binding of ³H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fischer-344 rats. No age-related differences in the association, equilibrium, or dissociation binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.

Original language	English (US)
Pages (from-to)	343-346
Number of pages	4
Journal	Life Sciences
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(82)90570-7
State	Published - Jan 25 1982
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(82)90570-7

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title = "Aging and benzodiazepine binding in the rat cerebral cortex",

abstract = "The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fischer-344 rats. No age-related differences in the association, equilibrium, or dissociation binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.",

author = "Tsang, {C. C.} and Speeg, {K. V.} and Wilkinson, {G. R.}",

note = "Funding Information: The technical assistance of Sherry Wang is greatly appreciated, and the research was supported by grant AG 01395 from the United States Public Health Service.",

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AU - Tsang, C. C.

AU - Speeg, K. V.

AU - Wilkinson, G. R.

N1 - Funding Information: The technical assistance of Sherry Wang is greatly appreciated, and the research was supported by grant AG 01395 from the United States Public Health Service.

PY - 1982/1/25

Y1 - 1982/1/25

N2 - The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fischer-344 rats. No age-related differences in the association, equilibrium, or dissociation binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.

AB - The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fischer-344 rats. No age-related differences in the association, equilibrium, or dissociation binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.

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Aging and benzodiazepine binding in the rat cerebral cortex

Abstract

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