Aging and benzodiazepine binding in the rat cerebral cortex

C. C. Tsang, K. V. Speeg, G. R. Wilkinson

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The specific binding of 3H-diazepam in the cerebral cortex was investigated in membrane preparations from 6 and 30 month old Fischer-344 rats. No age-related differences in the association, equilibrium, or dissociation binding characteristics were observed. The increased sensitivity of the elderly to the central sedative effects of the benzodiazepines does not, therefore, appear to involve changes in binding to the receptor site located in the cortex.

Original languageEnglish (US)
Pages (from-to)343-346
Number of pages4
JournalLife Sciences
Issue number4
StatePublished - Jan 25 1982
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)


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