Aged limbic system. Interactions of estrogen with catecholaminergic and peptidergic synaptic transmissions

N. Hagino

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In this review the structural and chemical nature of the input fibers of hippocampus and their relationships to estrogen-ceptive neurons were discussed. The interactions of estrogen with catecholaminergic and peptidergic synaptic transmissions concerning limbic function became apparent; the cyclic changes in circulating estrogen in the reproductive animals create the cyclic changes in the activity of the hippocampal function; therefore, in the aged animals, the cessation of cyclic changes in circulating estrogen suppresses the activity of hippocampal function, and thus may lead to the initiation of Alzheimer's disease in man.

Original languageEnglish (US)
Pages (from-to)85-108
Number of pages24
JournalBiomedical Research
Volume2
Issue number2
DOIs
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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