Age, sex, and smoking are predictors of circulating insulin-like growth factor I and insulin-like growth factor-binding protein 3

Virginia G. Kaklamani, Athena Linos, Evangelia Kaklamani, Ioanna Markaki, Christos Mantzoros

Research output: Contribution to journalArticlepeer-review

97 Scopus citations

Abstract

Purpose: Insulin-like growth factor (IGF-1) and its major binding protein (IGF-BP3) have recently been implicated in the pathogenesis of several malignancies. However, anthropometric and lifestyle predictors of these hormones have not been elucidated. Here we report the results of a cross-sectional study. Subjects and Methods: This cross-sectional study examines the relationship of a series of epidemiologic parameters (age, sex, height, body mass index, smoking, alcohol consumption, and coffee drinking) with IGF-1 and IGF-BP3 in a sample of 130 healthy adults. Results: We observed that serum levels of IGF-1 are higher, whereas levels of IGF-BP3 are lower, in men than in women. In addition, serum levels of IGF-1 are independently and negatively associated with age and positively associated with pack-year history of smoking. Finally, serum levels of IGF-BP3 are independently and negatively associated with the number of cigarettes smoked per day or pack-year history of smoking. Conclusion: Age, sex, and smoking are independent predictors of IGF-1 and/or IGF-BP3. The influence of these epidemiologic variables on the pathogenesis of disease states associated with IGF-1 and IGF-BP3 warrants further exploration.

Original languageEnglish (US)
Pages (from-to)813-817
Number of pages5
JournalJournal of Clinical Oncology
Volume17
Issue number3
DOIs
StatePublished - Mar 1999
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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