Age-related progression of tau pathology in brains of baboons

Christian Schultz, G. B. Hubbard, U. Rüb, Eva Braak, Heiko Braak

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Recently, cytoskeletal changes associated with abnormally phosphorylated tau protein were demonstrated in neurons and glial cells of two aged baboons (Papio). The present study examines the effects of age on the development of tau pathology in baboons. Brains of 50 baboons ranging in age from 1 to 30 years were categorized into four age groups: Group I: 1-10 years [n = 9], group II: 11-20 years [n = 13], group III: 21-25 years [n = 17], group IV: 26-30 years [n = 11]). Whole hemisphere sections (100 μm) were examined using phosphorylation-dependent anti-tau antibodies. Cytoskeletal changes were completely absent in animals of group I. In group II four animals (31%) exhibited cytoskeletal changes which were rated as mild or moderate. In group III abnormal tau was found in 12 brains (71%) ranging in severity from mild to severe. Finally, in group IV 10 out of 11 animals (91%) exhibited some degree of tau pathology which was rated as severe in 4 animals (36%). A statistically significant relationship was found between advancing age and progression of tau pathology in baboons. In conclusion, the present findings underline the value of the baboon as a potential nonhuman primate model for age-related tau pathology afflicting the human brain. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)905-912
Number of pages8
JournalNeurobiology of Aging
Volume21
Issue number6
DOIs
StatePublished - Dec 28 2000
Externally publishedYes

Keywords

  • Aging
  • Alzheimer's disease
  • Animal model
  • Baboon
  • Nonhuman primates
  • Tau pathology
  • Tau-protein

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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