Age-related morphology trends of cortical sulci

Peter Kochunov; Jean François Mangin; Thomas Coyle; Jack Lancaster; Paul Thompson; Dennis Rivière; Yann Cointepas; Jean Régis; Anita Schlosser; Don R. Royall; Karl Zilles; John Mazziotta; Arthur Toga; Peter T. Fox

doi:10.1002/hbm.20198

Age-related morphology trends of cortical sulci

Peter Kochunov, Jean François Mangin, Thomas Coyle, Jack Lancaster, Paul Thompson, Dennis Rivière, Yann Cointepas, Jean Régis, Anita Schlosser, Don R. Royall, Karl Zilles, John Mazziotta, Arthur Toga, Peter T. Fox

Research output: Contribution to journal › Article › peer-review

194 Scopus citations

Abstract

The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).

Original language	English (US)
Pages (from-to)	210-220
Number of pages	11
Journal	Human Brain Mapping
Volume	26
Issue number	3
DOIs	https://doi.org/10.1002/hbm.20198
State	Published - Nov 2005

ASJC Scopus subject areas

Clinical Neurology
Neurology
Radiological and Ultrasound Technology
Radiology Nuclear Medicine and imaging
Anatomy

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10.1002/hbm.20198

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@article{1cac93a172264ad9a4bf6c305c5d65d2,

title = "Age-related morphology trends of cortical sulci",

abstract = "The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).",

author = "Peter Kochunov and Mangin, \{Jean Fran{\c c}ois\} and Thomas Coyle and Jack Lancaster and Paul Thompson and Dennis Rivi{\`e}re and Yann Cointepas and Jean R{\'e}gis and Anita Schlosser and Royall, \{Don R.\} and Karl Zilles and John Mazziotta and Arthur Toga and Fox, \{Peter T.\}",

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doi = "10.1002/hbm.20198",

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T1 - Age-related morphology trends of cortical sulci

AU - Kochunov, Peter

AU - Mangin, Jean François

AU - Coyle, Thomas

AU - Lancaster, Jack

AU - Thompson, Paul

AU - Rivière, Dennis

AU - Cointepas, Yann

AU - Régis, Jean

AU - Schlosser, Anita

AU - Royall, Don R.

AU - Zilles, Karl

AU - Mazziotta, John

AU - Toga, Arthur

AU - Fox, Peter T.

PY - 2005/11

Y1 - 2005/11

N2 - The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).

AB - The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).

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JO - Human Brain Mapping

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IS - 3

ER -

Age-related morphology trends of cortical sulci

Abstract

ASJC Scopus subject areas

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