Age-related morphology trends of cortical sulci

Peter Kochunov, Jean François Mangin, Thomas Coyle, Jack L Lancaster, Paul Thompson, Dennis Rivière, Yann Cointepas, Jean Régis, Anita Schlosser, Donald R Royall, Karl Zilles, John Mazziotta, Arthur Toga, Peter T Fox

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Abstract

The age-related trends of the width and the depth of major cortical sulci were studied in normal adults. Ninety healthy subjects (47 males, 43 females) age 20-82 years were evaluated. Measurements of average sulcal width and depth in 14 prominent sulcal structures per hemisphere were performed with high-resolution anatomical MRI. The average sulcal width increased at a rate of about 0.7 mm/decade, while the average sulcal depth decreased at a rate of about 0.4 mm/decade. Sulcal age-related trends were found to be highly influenced by gender in the superior temporal, collateral, and cingulate sulci (P < 0.05), with males showing more pronounced age-related change in sulcal width than females. Sulcal structures located in multimodal cortical areas showed more profound age-related changes than sulcal structures in unimodal cortical areas (P < 0.05).

Original languageEnglish (US)
Pages (from-to)210-220
Number of pages11
JournalHuman Brain Mapping
Volume26
Issue number3
DOIs
StatePublished - Nov 2005

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ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

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Kochunov, P., Mangin, J. F., Coyle, T., Lancaster, J. L., Thompson, P., Rivière, D., ... Fox, P. T. (2005). Age-related morphology trends of cortical sulci. Human Brain Mapping, 26(3), 210-220. https://doi.org/10.1002/hbm.20198

Age-related morphology trends of cortical sulci. / Kochunov, Peter; Mangin, Jean François; Coyle, Thomas; Lancaster, Jack L; Thompson, Paul; Rivière, Dennis; Cointepas, Yann; Régis, Jean; Schlosser, Anita; Royall, Donald R; Zilles, Karl; Mazziotta, John; Toga, Arthur; Fox, Peter T.

In: Human Brain Mapping, Vol. 26, No. 3, 11.2005, p. 210-220.

Research output: Contribution to journalArticle

Kochunov, P, Mangin, JF, Coyle, T, Lancaster, JL, Thompson, P, Rivière, D, Cointepas, Y, Régis, J, Schlosser, A, Royall, DR, Zilles, K, Mazziotta, J, Toga, A & Fox, PT 2005, 'Age-related morphology trends of cortical sulci', Human Brain Mapping, vol. 26, no. 3, pp. 210-220. https://doi.org/10.1002/hbm.20198
Kochunov P, Mangin JF, Coyle T, Lancaster JL, Thompson P, Rivière D et al. Age-related morphology trends of cortical sulci. Human Brain Mapping. 2005 Nov;26(3):210-220. https://doi.org/10.1002/hbm.20198
Kochunov, Peter ; Mangin, Jean François ; Coyle, Thomas ; Lancaster, Jack L ; Thompson, Paul ; Rivière, Dennis ; Cointepas, Yann ; Régis, Jean ; Schlosser, Anita ; Royall, Donald R ; Zilles, Karl ; Mazziotta, John ; Toga, Arthur ; Fox, Peter T. / Age-related morphology trends of cortical sulci. In: Human Brain Mapping. 2005 ; Vol. 26, No. 3. pp. 210-220.
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