Age related decline in cytoplasmic spreading of mouse peritoneal macrophages

David R. Johnson, Gabriel Fernandes, Steven D. Douglas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Peritoneal macrophages fron NZB, C3H/f and CBA/H mice are examined for age-related changes in cytoplasmic spreading. A significant reduction in the ability to spread on antigen-antibody complex coated glass was observed with age for macrophages from all three strains. A significant decline in spreading on uncoated glass was also seen in NZB and C3H/f macrophages. The age-related decline in cytoplasmic spreading was strain-dependent and appeared to correlate with differences in lifespan.

Original languageEnglish (US)
Pages (from-to)347-354
Number of pages8
JournalDevelopmental and Comparative Immunology
Issue number2
StatePublished - 1978
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology


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