Peritoneal macrophages fron NZB, C3H/f and CBA/H mice are examined for age-related changes in cytoplasmic spreading. A significant reduction in the ability to spread on antigen-antibody complex coated glass was observed with age for macrophages from all three strains. A significant decline in spreading on uncoated glass was also seen in NZB and C3H/f macrophages. The age-related decline in cytoplasmic spreading was strain-dependent and appeared to correlate with differences in lifespan.
ASJC Scopus subject areas
- Developmental Biology