Age related decline in cytoplasmic spreading of mouse peritoneal macrophages

David R. Johnson; Gabriel Fernandes; Steven D. Douglas

doi:10.1016/S0145-305X(78)80077-9

Age related decline in cytoplasmic spreading of mouse peritoneal macrophages

David R. Johnson, Gabriel Fernandes, Steven D. Douglas

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Peritoneal macrophages fron NZB, C3H/f and CBA/H mice are examined for age-related changes in cytoplasmic spreading. A significant reduction in the ability to spread on antigen-antibody complex coated glass was observed with age for macrophages from all three strains. A significant decline in spreading on uncoated glass was also seen in NZB and C3H/f macrophages. The age-related decline in cytoplasmic spreading was strain-dependent and appeared to correlate with differences in lifespan.

Original language	English (US)
Pages (from-to)	347-354
Number of pages	8
Journal	Developmental and Comparative Immunology
Volume	2
Issue number	2
DOIs	https://doi.org/10.1016/S0145-305X(78)80077-9
State	Published - 1978
Externally published	Yes

ASJC Scopus subject areas

Immunology
Developmental Biology

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10.1016/S0145-305X(78)80077-9

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title = "Age related decline in cytoplasmic spreading of mouse peritoneal macrophages",

abstract = "Peritoneal macrophages fron NZB, C3H/f and CBA/H mice are examined for age-related changes in cytoplasmic spreading. A significant reduction in the ability to spread on antigen-antibody complex coated glass was observed with age for macrophages from all three strains. A significant decline in spreading on uncoated glass was also seen in NZB and C3H/f macrophages. The age-related decline in cytoplasmic spreading was strain-dependent and appeared to correlate with differences in lifespan.",

author = "Johnson, {David R.} and Gabriel Fernandes and Douglas, {Steven D.}",

note = "Funding Information: Acknowledgements: This work was supported by grants from the National Institutes of Health, USPHS AI 12478, CA-Ag 21084, the Kroc Foundation, Santa Ynes, Ca.",

year = "1978",

doi = "10.1016/S0145-305X(78)80077-9",

language = "English (US)",

volume = "2",

pages = "347--354",

journal = "Developmental and Comparative Immunology",

issn = "0145-305X",

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TY - JOUR

T1 - Age related decline in cytoplasmic spreading of mouse peritoneal macrophages

AU - Johnson, David R.

AU - Fernandes, Gabriel

AU - Douglas, Steven D.

N1 - Funding Information: Acknowledgements: This work was supported by grants from the National Institutes of Health, USPHS AI 12478, CA-Ag 21084, the Kroc Foundation, Santa Ynes, Ca.

PY - 1978

Y1 - 1978

N2 - Peritoneal macrophages fron NZB, C3H/f and CBA/H mice are examined for age-related changes in cytoplasmic spreading. A significant reduction in the ability to spread on antigen-antibody complex coated glass was observed with age for macrophages from all three strains. A significant decline in spreading on uncoated glass was also seen in NZB and C3H/f macrophages. The age-related decline in cytoplasmic spreading was strain-dependent and appeared to correlate with differences in lifespan.

AB - Peritoneal macrophages fron NZB, C3H/f and CBA/H mice are examined for age-related changes in cytoplasmic spreading. A significant reduction in the ability to spread on antigen-antibody complex coated glass was observed with age for macrophages from all three strains. A significant decline in spreading on uncoated glass was also seen in NZB and C3H/f macrophages. The age-related decline in cytoplasmic spreading was strain-dependent and appeared to correlate with differences in lifespan.

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U2 - 10.1016/S0145-305X(78)80077-9

DO - 10.1016/S0145-305X(78)80077-9

M3 - Article

C2 - 680307

AN - SCOPUS:0018104381

SN - 0145-305X

VL - 2

SP - 347

EP - 354

JO - Developmental and Comparative Immunology

JF - Developmental and Comparative Immunology

IS - 2

ER -

Age related decline in cytoplasmic spreading of mouse peritoneal macrophages

Abstract

ASJC Scopus subject areas

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