Age-related changes in unscheduled DNA synthesis by rat hepatocytes

Marguerite M. Plesko, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.

Original languageEnglish (US)
Pages (from-to)730-735
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Feb 14 1984

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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