Age-related changes in unscheduled DNA synthesis by rat hepatocytes

Marguerite M. Plesko; Arlan Richardson

doi:10.1016/0006-291X(84)91455-4

Age-related changes in unscheduled DNA synthesis by rat hepatocytes

Marguerite M. Plesko, Arlan Richardson

Barshop Institute

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.

Original language	English (US)
Pages (from-to)	730-735
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	118
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(84)91455-4
State	Published - Feb 14 1984

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1016/0006-291X(84)91455-4

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title = "Age-related changes in unscheduled DNA synthesis by rat hepatocytes",

abstract = "Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.",

author = "Plesko, {Marguerite M.} and Arlan Richardson",

note = "Funding Information: We are grateful to Dr. the statistical analyses. from the National Institutes Alan Katz and J. Daniel House for assistance with The research was supported by a grant (AG 0154B) of Health.",

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AU - Richardson, Arlan

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N2 - Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.

AB - Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.

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Age-related changes in unscheduled DNA synthesis by rat hepatocytes

Abstract

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