Age-related changes in the corneal endothelium of the rat

K. L. Fitch, M. J. Nadakavukaren, A. Richardson

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


The endothelial cells of the rat cornea show a progressive decline in numbers and an increase in pleomorphism from age 6 months to 30 months. These age-related changes correspond closely to those reported in the human cornea from approximately age 20 to age 70 years. The corneal endothelium may be found useful as an index of physiological aging in these and other mammals.

Original languageEnglish (US)
Pages (from-to)179-183
Number of pages5
JournalExperimental Gerontology
Issue number3
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology


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