Age-related changes in the corneal endothelium of the rat

K. L. Fitch; M. J. Nadakavukaren; A. Richardson

doi:10.1016/0531-5565(82)90023-7

Age-related changes in the corneal endothelium of the rat

K. L. Fitch, M. J. Nadakavukaren, A. Richardson

Barshop Institute

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The endothelial cells of the rat cornea show a progressive decline in numbers and an increase in pleomorphism from age 6 months to 30 months. These age-related changes correspond closely to those reported in the human cornea from approximately age 20 to age 70 years. The corneal endothelium may be found useful as an index of physiological aging in these and other mammals.

Original language	English (US)
Pages (from-to)	179-183
Number of pages	5
Journal	Experimental Gerontology
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0531-5565(82)90023-7
State	Published - 1982

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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abstract = "The endothelial cells of the rat cornea show a progressive decline in numbers and an increase in pleomorphism from age 6 months to 30 months. These age-related changes correspond closely to those reported in the human cornea from approximately age 20 to age 70 years. The corneal endothelium may be found useful as an index of physiological aging in these and other mammals.",

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