Age-related changes in protein, RNA and DNA content and protein synthesis in rat testes

Daniel S.H. Liu, Rick Ekstrom, John W. Spicer, Arlan Richardson

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Changes in the content of protein, RNA, and DNA and cell-free synthesis of testes from Fischer F344 rats of various ages were studied. The protein, RNA, and DNA content of the testicular tissue decreased slightly from 3 to 20 months; however, an increase in the content of these macromolecules was observed from 18 to 30 months. Protein synthesis by the post-mitochondrial supernatant of testes from 3 to 30 month old rats decreased 47% with age. The largest decrease in protein synthesis occured from 12 to 20 months. The decreased cell-free protein synthetic activity was due to both microsomal and post-microsomal factors in the testicular post-mitochondrial supernatant.

Original languageEnglish (US)
Pages (from-to)197-205
Number of pages9
JournalExperimental Gerontology
Volume13
Issue number3-4
DOIs
StatePublished - 1978

ASJC Scopus subject areas

  • Biochemistry
  • Aging
  • Molecular Biology
  • Genetics
  • Endocrinology
  • Cell Biology

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