Age-dependent reversal of the lobular distribution of androgen-inducible α(2u) globulin and androgen-repressible SMP-2 in rat liver

M. A. Mancini, B. Chatterjee, A. K. Roy

Research output: Contribution to journalArticle

13 Scopus citations


Hepatocytes situated at pericentral and periportal zones of the liver lobule show differences in the expression of several liver-specific genes, such as androgen-inducible α(2u) globulin and androgen-repressible senescence marker protein-2 (SMP-2). A marked temporal difference in the expression of these two androgen-regulated genes has also been observed. The liver of the pre-pubertal male rat is insensitive to androgen, and during this period hepatocytes synthesize only SMP-2. During young adult life (>40 days), the liver becomes androgen sensitive and concomitant synthesis of α(2u) globulin and repression of SMP-2 occur. In the senescent male rat (>750 days), the liver again becomes androgen insensitive when the decline in α(2u) globulin is accompanied by an increase in SMP-2 synthesis. In this article we present results to show a correlation between the temporal and spatial (intralobular) changes in the expression of the androgen-inducible α(2u) globulin and the androgen-repressible SMP-2 in rat hepatocytes. Results indicate that the temporal changes in hepatic androgen sensitivity are dictated by the intralobular location of the hepatocytes. Hepatocytes located around the central vein (pericentral/perivenous) may benefit from a paracrine advantage for the expression of a subset of genes, including the gene for the androgen receptor.

Original languageEnglish (US)
Pages (from-to)401-405
Number of pages5
JournalJournal of Histochemistry and Cytochemistry
Issue number4
Publication statusPublished - Jan 1 1991



  • Aging Paracrine effect
  • Androgen induction
  • Cell heterogeneity
  • Cell-cell interactions
  • Hepatic proteins
  • Immunocytochemistry
  • Rat
  • Senescence marker protein-2
  • α(2u) globulin

ASJC Scopus subject areas

  • Anatomy
  • Histology

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