Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Mohammad A. Pahlavani; Arlan Richardson; H. Tak Cheung

doi:10.1016/0047-6374(87)90005-4

Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Mohammad A. Pahlavani, Arlan Richardson, H. Tak Cheung

Barshop Institute

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.

Original language	English (US)
Pages (from-to)	137-146
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0047-6374(87)90005-4
State	Published - Jul 1987

Keywords

Age
Histometric
Lymph node
Morphology
Rat

ASJC Scopus subject areas

Aging
Developmental Biology

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title = "Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis",

abstract = "Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.",

keywords = "Age, Histometric, Lymph node, Morphology, Rat",

author = "Pahlavani, {Mohammad A.} and Arlan Richardson and {Tak Cheung}, H.",

note = "Funding Information: This work was supported by Grant AG 04520 and AI 20343 from National Institutes of Health, Bethesda, MD. The authors would also like to thank Dr. T.I. Chuang for the technical advice on the morphological studies and Ms. Joni St. John in the preparation of the manuscript.",

year = "1987",

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T1 - Age-dependent changes of the mesenteric lymph node of fischer F344 rats

T2 - Morphological and Histometric analysis

AU - Pahlavani, Mohammad A.

AU - Richardson, Arlan

AU - Tak Cheung, H.

N1 - Funding Information: This work was supported by Grant AG 04520 and AI 20343 from National Institutes of Health, Bethesda, MD. The authors would also like to thank Dr. T.I. Chuang for the technical advice on the morphological studies and Ms. Joni St. John in the preparation of the manuscript.

PY - 1987/7

Y1 - 1987/7

N2 - Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.

AB - Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.

KW - Age

KW - Histometric

KW - Lymph node

KW - Morphology

KW - Rat

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Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Abstract

Keywords

ASJC Scopus subject areas

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