Abstract
Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 137-146 |
| Number of pages | 10 |
| Journal | Mechanisms of Ageing and Development |
| Volume | 39 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1987 |
| Externally published | Yes |
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Keywords
- Age
- Histometric
- Lymph node
- Morphology
- Rat
ASJC Scopus subject areas
- Aging
- Biochemistry
- Developmental Biology
- Developmental Neuroscience
Cite this
Age-dependent changes of the mesenteric lymph node of fischer F344 rats : Morphological and Histometric analysis. / Pahlavani, Mohammad A.; Richardson, Arlan; Tak Cheung, H.
In: Mechanisms of Ageing and Development, Vol. 39, No. 2, 1987, p. 137-146.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Age-dependent changes of the mesenteric lymph node of fischer F344 rats
T2 - Morphological and Histometric analysis
AU - Pahlavani, Mohammad A.
AU - Richardson, Arlan
AU - Tak Cheung, H.
PY - 1987
Y1 - 1987
N2 - Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.
AB - Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.
KW - Age
KW - Histometric
KW - Lymph node
KW - Morphology
KW - Rat
UR - http://www.scopus.com/inward/record.url?scp=0023221775&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023221775&partnerID=8YFLogxK
U2 - 10.1016/0047-6374(87)90005-4
DO - 10.1016/0047-6374(87)90005-4
M3 - Article
C2 - 3626638
AN - SCOPUS:0023221775
VL - 39
SP - 137
EP - 146
JO - Mechanisms of Ageing and Development
JF - Mechanisms of Ageing and Development
SN - 0047-6374
IS - 2
ER -