Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Mohammad A. Pahlavani, Arlan Richardson, H. Tak Cheung

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.

Original languageEnglish (US)
Pages (from-to)137-146
Number of pages10
JournalMechanisms of Ageing and Development
Volume39
Issue number2
DOIs
StatePublished - Jul 1987

Keywords

  • Age
  • Histometric
  • Lymph node
  • Morphology
  • Rat

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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