Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Mohammad A. Pahlavani; Arlan Richardson; H. Tak Cheung

doi:10.1016/0047-6374(87)90005-4

Age-dependent changes of the mesenteric lymph node of fischer F344 rats: Morphological and Histometric analysis

Mohammad A. Pahlavani, Arlan Richardson, H. Tak Cheung

Barshop Institute

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.

Original language	English (US)
Pages (from-to)	137-146
Number of pages	10
Journal	Mechanisms of Ageing and Development
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0047-6374(87)90005-4
State	Published - Jul 1987

Keywords

Age
Histometric
Lymph node
Morphology
Rat

ASJC Scopus subject areas

Aging
Developmental Biology

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abstract = "Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.",

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