Abstract
Changes in mesenteric lymph nodes from Fischer F344 rats ranging from 5 to 37 months were studied by histological and histometric techniques. The most drastic histological changes were observed between 12 and 37 months of age. These changes include: (1) loss of cellularity in the cortex; (2) decrease in the number of germinal centers; (3) distension of the medullary sinuses; (4) decrease in the ratio of cortical area to medullary area; and (5) infiltration of fibroblastic cells in the cortex and the medulla. Our results indicate a general structural disorganization in the mesenteric lymph node with increasing age. Such structural disturbance might be an important extrinsic factor for the decline in lymphocyte functions.
Original language | English (US) |
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Pages (from-to) | 137-146 |
Number of pages | 10 |
Journal | Mechanisms of Ageing and Development |
Volume | 39 |
Issue number | 2 |
DOIs | |
State | Published - Jul 1987 |
Externally published | Yes |
Keywords
- Age
- Histometric
- Lymph node
- Morphology
- Rat
ASJC Scopus subject areas
- Aging
- Developmental Biology