Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains

T. P.U. Wustrow; T. N. Denny; G. Fernandes; R. A. Good

doi:10.1016/0008-8749(84)90311-3

Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains

T. P.U. Wustrow, T. N. Denny, G. Fernandes, R. A. Good

Medicine

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Comparisons were made with age on phagocytosis, chemotaxis, and esterase staining of autoimmune-resistant and autoimmune-susceptible mouse strains. Consistent increases of each parameter occurred with age. Autoimmune strains generally showed less change with age than autoimmune-resistant mice and the changes with aging were less consistent These findings suggest that phagocytic cells may play an important role in the autoimmunities or the lymphoproliferative processes that occur in autoimmune-prone mice and/or in loss of immune function with aging.

Original language	English (US)
Pages (from-to)	321-329
Number of pages	9
Journal	Cellular Immunology
Volume	83
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(84)90311-3
State	Published - Feb 1984

ASJC Scopus subject areas

Immunology

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AU - Fernandes, G.

AU - Good, R. A.

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AB - Comparisons were made with age on phagocytosis, chemotaxis, and esterase staining of autoimmune-resistant and autoimmune-susceptible mouse strains. Consistent increases of each parameter occurred with age. Autoimmune strains generally showed less change with age than autoimmune-resistant mice and the changes with aging were less consistent These findings suggest that phagocytic cells may play an important role in the autoimmunities or the lymphoproliferative processes that occur in autoimmune-prone mice and/or in loss of immune function with aging.

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