Age-associated reduction in pineal beta-adrenergic receptor density is prevented by life-long food restriction in rats.

T. Henden, K. A. Stokkan, R. J. Reiter, K. O. Nonaka, A. Lerchl, D. J. Jones

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

At 28 months of age (old rats), male Fisher 344 rats which had been fed 40% of the ad libitum food intake since they were 6 months old, had a similar beta-adrenergic receptor density (Bmax) in their pineal gland as young, 3-month-old rats. In contrast, old rats which had been fed ad libitum for the same period had approximately 50% of the Bmax value compared to that of young rats. The beta-receptor density of cerebral cortical tissue and the beta-receptor affinity (Kd) of both the cortex and the pineal gland did not decline with age and was not affected by food restriction. The reduction in pineal beta-receptor density with age may be casually related to the concurrent age-associated decline in pineal production of melatonin.

Original languageEnglish (US)
Pages (from-to)34-39
Number of pages6
JournalBiological signals
Volume1
Issue number1
DOIs
StatePublished - 1992

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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