Age-associated changes in pineal serotonin n-acetyltransferase activity and melatonin content in the Male gerbil

Thomas S. King, Bruce A. Richardson, Russel J. Reíter

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Pineal serotonin N-acetyltransferase (NAT) activity and melatonin content were measured in 2- and 15-month old male gerbils at various times over a 24h light: dark cycle (LD 14:10). A nocturnal increase over the low daytime values in NAT activity and melatonin content was noted in both 2- and 15-month old gerbils, suggesting the continued existence of a circadian rhythm in each of these biochemical parameters of pineal secretory function at least until 15-months of age. Notable differences in the levels of NAT activity and melatonin content between 2- and 15-month old gerbils included (1) a phase shift in peak NAT activity and melatonin content in 15-month old versus 2-month old gerbils and (2) a latent decrease in NAT activity in 15-month old gerbils after the onset of the light period relative to that in 2-month old gerbils.

Original languageEnglish (US)
Pages (from-to)253-262
Number of pages10
JournalEndocrine Research
Volume8
Issue number4
DOIs
StatePublished - Jan 1 1981

ASJC Scopus subject areas

  • Endocrinology

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