Age Associated Alterations in Costimulatory and Adhesion Molecule Expression in Lupus-Prone Mice Are Attenuated by Food Restriction with n-6 and n-3 Fatty Acids

Alagarraju Muthukumar, Dongxu Sun, Khaliquz Zaman, J. L. Barnes, David Haile, Gabriel Fernandes

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Costimulatory and adhesion molecules are known to play a major role in the pathogenesis of systemic lupus erythematosus. Since fish oil and calorie restriction have been reported to attenuate the development of disease in lupus prone (NZBxNZW)F1 mice, the objective of this study was to assess the expression of these key inflammatory molecules in these mice fed diets differing in n-6 and n-3 fatty acid content and fed either food restricted or ad libitum. Age-associated increases in the expression of CD28, ICAM-1, and PGP-1 molecules that are involved in the recruitment of inflamed lymphocytes into the kidney were attenuated in mice restricted in food intake. The increase in costimulatory (CD80 and CD86) and adhesion (ICAM-1, PGP-1, LFA-1, and Mac-1) in peripheral blood mononuclear cells was also attenuated by food restriction and to a lesser extent by fish oil alone. Interestingly, amelioration of lupus (laminin expression and proteinuria) correlated with the above beneficial effects and could be seen even in 24-month-old mice. In summary, food restriction and fish oil delay the onset of lupus disease and increase life span in B/W mice by prolonging the maintenance of a youthful immune phenotype.

Original languageEnglish (US)
Pages (from-to)471-480
Number of pages10
JournalJournal of Clinical Immunology
Volume24
Issue number5
DOIs
StatePublished - Sep 1 2004

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Keywords

  • Autoimmune disease
  • B/W mice
  • adhesion molecules
  • costimulatory molecules
  • fish oil
  • food restriction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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