TY - JOUR
T1 - Age Associated Alterations in Costimulatory and Adhesion Molecule Expression in Lupus-Prone Mice Are Attenuated by Food Restriction with n-6 and n-3 Fatty Acids
AU - Muthukumar, Alagarraju
AU - Sun, Dongxu
AU - Zaman, Khaliquz
AU - Barnes, J. L.
AU - Haile, David
AU - Fernandes, Gabriel
PY - 2004/9/1
Y1 - 2004/9/1
N2 - Costimulatory and adhesion molecules are known to play a major role in the pathogenesis of systemic lupus erythematosus. Since fish oil and calorie restriction have been reported to attenuate the development of disease in lupus prone (NZBxNZW)F1 mice, the objective of this study was to assess the expression of these key inflammatory molecules in these mice fed diets differing in n-6 and n-3 fatty acid content and fed either food restricted or ad libitum. Age-associated increases in the expression of CD28, ICAM-1, and PGP-1 molecules that are involved in the recruitment of inflamed lymphocytes into the kidney were attenuated in mice restricted in food intake. The increase in costimulatory (CD80 and CD86) and adhesion (ICAM-1, PGP-1, LFA-1, and Mac-1) in peripheral blood mononuclear cells was also attenuated by food restriction and to a lesser extent by fish oil alone. Interestingly, amelioration of lupus (laminin expression and proteinuria) correlated with the above beneficial effects and could be seen even in 24-month-old mice. In summary, food restriction and fish oil delay the onset of lupus disease and increase life span in B/W mice by prolonging the maintenance of a youthful immune phenotype.
AB - Costimulatory and adhesion molecules are known to play a major role in the pathogenesis of systemic lupus erythematosus. Since fish oil and calorie restriction have been reported to attenuate the development of disease in lupus prone (NZBxNZW)F1 mice, the objective of this study was to assess the expression of these key inflammatory molecules in these mice fed diets differing in n-6 and n-3 fatty acid content and fed either food restricted or ad libitum. Age-associated increases in the expression of CD28, ICAM-1, and PGP-1 molecules that are involved in the recruitment of inflamed lymphocytes into the kidney were attenuated in mice restricted in food intake. The increase in costimulatory (CD80 and CD86) and adhesion (ICAM-1, PGP-1, LFA-1, and Mac-1) in peripheral blood mononuclear cells was also attenuated by food restriction and to a lesser extent by fish oil alone. Interestingly, amelioration of lupus (laminin expression and proteinuria) correlated with the above beneficial effects and could be seen even in 24-month-old mice. In summary, food restriction and fish oil delay the onset of lupus disease and increase life span in B/W mice by prolonging the maintenance of a youthful immune phenotype.
KW - Autoimmune disease
KW - B/W mice
KW - adhesion molecules
KW - costimulatory molecules
KW - fish oil
KW - food restriction
UR - http://www.scopus.com/inward/record.url?scp=4544375557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=4544375557&partnerID=8YFLogxK
U2 - 10.1023/B:JOCI.0000040918.92219.d1
DO - 10.1023/B:JOCI.0000040918.92219.d1
M3 - Article
C2 - 15359106
AN - SCOPUS:4544375557
VL - 24
SP - 471
EP - 480
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
SN - 0271-9142
IS - 5
ER -