Age as a determinant of sensitivity to warfarin.

AM Shepherd, DS Hewick, TA Moreland, IH Stevenson

Research output: Contribution to journalArticle

178 Scopus citations

Abstract

1 Parallel human and rat studies were carried out to confirm the previous suggestion of an increased sensitivity to warfarin in old age. 2 The anticoagulant response to warfarin was found to be greater in the elderly groups despite, in the case of the patient study, the elderly subjects being given a smaller weight‐related dose. 3 At the same plasma warfarin concentrations there was greater inhibition of vitamin K‐dependent clotting factor synthesis in the elderly. There was no difference in the rate of clotting factor degradation in the two age groups. 4 There was no appreciable difference in warfarin pharmacokinetics (plasma half‐life, apparent volume of distribution, plasma clearance, plasma protein binding or plasma warfarin alcohol levels) in the two age groups. 5 There appeared to be no major age‐ related differences in warfarin pharmacokinetics and the increased effect of warfarin in the elderly seemed to result from an increased intrinsic sensitivity to warfarin. 1977 The British Pharmacological Society

Original languageEnglish (US)
Pages (from-to)315-320
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume4
Issue number3
DOIs
StatePublished - Jun 1977
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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