Age and training alter collagen characteristics in fast- and slow-twitch rat limb muscle

S. D. Zimmerman, R. J. McCormick, Ratna K Vadlamudi, D. P. Thomas

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

This study evaluated the single and interactive effects of age and training status on selected collagen parameters in two rodent locomotor skeletal muscles contrasting in fiber type composition. Gastrocnemius (GAST) and soleus (SOL) muscles from both trained (10 wk of daily treadmill running) and sedentary young adult (5-mo-old), middle-aged (15-mo-old), and old (23- mo-old) female Fischer 344 rats were evaluated for concentrations of collagen {measured by hydroxyproline concentration ([OH-Pro])} and of the predominant nonreducible lysine aldehyde-derived collagen cross-link hydroxylysylpyridinoline ([HP]). Maximal aerobic capacity was significantly elevated in all three trained groups compared with sedentary age-matched control groups. Slow-twitch SOL had a significantly higher [OH-Pro] than fast-twitch GAST (P < 0.05). Although aging had no effect on [OH-Pro] in GAST, in SOL a significant increase with age was seen (P < 0.02). In sedentary rats both GAST and SOL [HP] increased with age, with this increase being more pronounced for SOL. Additionally, although training had no effect on the aging-associated increase in GAST [HP], it prevented the rise seen in SOL. The observed training-induced reduction in SOL [HP] presumably reflects exercise recruitment and subsequent stimulation of collagen synthesis and degradation rates in this muscle. We conclude that both aging and training affect the extracellular matrix in rodent limb skeletal muscle.

Original languageEnglish (US)
Pages (from-to)1670-1674
Number of pages5
JournalJournal of Applied Physiology
Volume75
Issue number4
StatePublished - 1993
Externally publishedYes

Fingerprint

Skeletal Muscle
Collagen
Extremities
Muscles
Rodentia
Hydroxyproline
Inbred F344 Rats
Aldehydes
Running
Lysine
Extracellular Matrix
Young Adult
Research Design
Exercise
Control Groups
pyridinoline
hydroxide ion

Keywords

  • cross-linking
  • fiber type
  • skeletal muscle collagen

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Age and training alter collagen characteristics in fast- and slow-twitch rat limb muscle. / Zimmerman, S. D.; McCormick, R. J.; Vadlamudi, Ratna K; Thomas, D. P.

In: Journal of Applied Physiology, Vol. 75, No. 4, 1993, p. 1670-1674.

Research output: Contribution to journalArticle

Zimmerman, S. D. ; McCormick, R. J. ; Vadlamudi, Ratna K ; Thomas, D. P. / Age and training alter collagen characteristics in fast- and slow-twitch rat limb muscle. In: Journal of Applied Physiology. 1993 ; Vol. 75, No. 4. pp. 1670-1674.
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