@inproceedings{a9dd89c3cc8145f68fb7b4d55689fe0f,
title = "Age and sex-associated changes in signal transduction and bone formation in primary human osteoblast/implant cultures",
abstract = "Age and sex-associated changes in signal transduction and bone formation in primary human osteoblast (HOB)/implant cultures are discussed. The differences in integrins and cell signaling that lead to changes in differentiation in HOB from aging patients were also investigated. Activation of integrins leads to a signaling cascade involving the phosphorylation of mitogen-activated protein kinases (MAPK), translocation of MAPK to the nucleus and activation of the AP-1 transcription complex. Osteoblasts from elderly female patients which had attached to Ti-6Al-4V, showed a different activation pattern of protein expression in the MAPK signaling pathway compared to HOB from younger patients and males of all ages.",
author = "Gronowicz, \{G. A.\} and H. Zhang",
year = "2004",
language = "English (US)",
isbn = "1877040193",
series = "Transactions - 7th World Biomaterials Congress",
pages = "120",
booktitle = "Transactions - 7th World Biomaterials Congress",
note = "Transactions - 7th World Biomaterials Congress ; Conference date: 17-05-2004 Through 21-05-2004",
}