Aerosolized antibiotics

Marcos I. Restrepo, Holly Keyt, Luis F. Reyes

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Administration of medications via aerosolization is potentially an ideal strategy to treat airway diseases. This delivery method ensures high concentrations of the medication in the targeted tissues, the airways, with generally lower systemic absorption and systemic adverse effects. Aerosolized antibiotics have been tested as treatment for bacterial infections in patients with cystic fibrosis (CF), non-CF bronchiectasis (NCFB), and ventilator-associated pneumonia (VAP). The most successful application of this to date is treatment of infections in patients with CF. It has been hypothesized that similar success would be seen in NCFB and in difficult-to-treat hospital-acquired infections such as VAP. This review summarizes the available evidence supporting the use of aerosolized antibiotics and addresses the specific considerations that clinicians should recognize when prescribing an aerosolized antibiotic for patients with CF, NCFB, and VAP.

Original languageEnglish (US)
Pages (from-to)762-770
Number of pages9
JournalRespiratory care
Volume60
Issue number6
DOIs
StatePublished - Jun 1 2015

Keywords

  • Aerosols
  • Antibacterial agents
  • Bronchiectasis
  • Cystic fibrosis (CF)
  • Ventilator-associated pneumonia (VAP)

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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