Adverse effects of fenfluramine in treatment refractory schizophrenia

Barringer D. Marshall, Shirley M. Glynn, Kamal K. Midha, John W. Hubbard, Linda L. Bowen, Lorelle Banzett, Jim Mintz, Robert P. Liberman

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses$#x2019; ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalJournal of Clinical Psychopharmacology
Issue number2
StatePublished - Apr 1989
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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