Adverse effects of fenfluramine in treatment refractory schizophrenia

B. D. Marshall, S. M. Glynn, K. K. Midha, J. W. Hubbard, L. L. Bowen, L. Banzett, Jim Mintz, R. P. Liberman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Fenfluramine was administered to eight severely ill schizophrenic patients as an adjunct to neuroleptic drugs in a double-blind, multiple baseline design. A significant adverse effect of fenfluramine on psychopathology was detected through nurses' ratings, target symptom scales, the Brief Psychiatric Rating Scale, and time-sampled behavioral observations. Clinical deterioration was correlated with fenfluramine-induced reductions in blood serotonin levels and persisted beyond the point of discontinuation of fenfluramine.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalJournal of Clinical Psychopharmacology
Volume9
Issue number2
StatePublished - 1989
Externally publishedYes

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Fenfluramine
Schizophrenia
Brief Psychiatric Rating Scale
Therapeutics
Psychopathology
Antipsychotic Agents
Serotonin
Nurses

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Psychiatry and Mental health
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Marshall, B. D., Glynn, S. M., Midha, K. K., Hubbard, J. W., Bowen, L. L., Banzett, L., ... Liberman, R. P. (1989). Adverse effects of fenfluramine in treatment refractory schizophrenia. Journal of Clinical Psychopharmacology, 9(2), 110-115.

Adverse effects of fenfluramine in treatment refractory schizophrenia. / Marshall, B. D.; Glynn, S. M.; Midha, K. K.; Hubbard, J. W.; Bowen, L. L.; Banzett, L.; Mintz, Jim; Liberman, R. P.

In: Journal of Clinical Psychopharmacology, Vol. 9, No. 2, 1989, p. 110-115.

Research output: Contribution to journalArticle

Marshall, BD, Glynn, SM, Midha, KK, Hubbard, JW, Bowen, LL, Banzett, L, Mintz, J & Liberman, RP 1989, 'Adverse effects of fenfluramine in treatment refractory schizophrenia', Journal of Clinical Psychopharmacology, vol. 9, no. 2, pp. 110-115.
Marshall BD, Glynn SM, Midha KK, Hubbard JW, Bowen LL, Banzett L et al. Adverse effects of fenfluramine in treatment refractory schizophrenia. Journal of Clinical Psychopharmacology. 1989;9(2):110-115.
Marshall, B. D. ; Glynn, S. M. ; Midha, K. K. ; Hubbard, J. W. ; Bowen, L. L. ; Banzett, L. ; Mintz, Jim ; Liberman, R. P. / Adverse effects of fenfluramine in treatment refractory schizophrenia. In: Journal of Clinical Psychopharmacology. 1989 ; Vol. 9, No. 2. pp. 110-115.
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