Adverse cardiodynamic effects of vasopressin not avoided by selective intra-arterial administration

Kenneth R. Sirinek, Neil R. Thomford, William G. Pace

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

In this study, lysine-vasopressin, administered either as a continuous, intravenous infusion (1 unit/kg/hour) or as a selective infusion into the superior mesenteric artery (0.2 unit/minute), produced equal (↓25%), significant (p < 0.05), and sustained (60 minute) reductions in portal pressure. Compared to intravenous administration, selective intra-arterial infusion of vasopressin resulted in similar reductions in cardiac output (↓38%), myocardial contractility (↓23%), and coronary flow (↓53%). Since these adverse cardiodynamic effects were not avoided by selective intra-arterial infusion, it would appear that administration of vasopressin as a continuous infusion through a peripheral vein remains the most rapid and practical method of administering the drug.

Original languageEnglish (US)
Pages (from-to)723-728
Number of pages6
JournalSurgery
Volume81
Issue number6
StatePublished - Jun 1977
Externally publishedYes

ASJC Scopus subject areas

  • Surgery

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