Abstract
The genetic similarity between humans and nonhuman primates makes nonhuman primates uniquely suited as models for genetic research on complex physiological and behavioral phenotypes. By comparison with human subjects, nonhuman primates, like other animal models, have several advantages for these types of studies: 1) constant environmental conditions can be maintained over long periods of time, greatly increasing the power to detect genetic effects; 2) different environmental conditions can be imposed sequentially on individuals to characterize genotype-environment interactions; 3) complex pedigrees that are much more powerful for genetic analysis than typically available human pedigrees can be generated; 4) genetic hypotheses can be tested prospectively by selective matings; and 5) essential invasive and terminal experiments can be conducted. Limitations of genetic research with nonhuman primates include cost and availability. However, the ability to manipulate both genetic and environmental factors in captive primate populations indicates the promise of genetic research with these important animal models for illuminating complex disease processes. The utility of nonhuman primates for biomedical research on human health problems is illustrated by examples concerning the use of baboons in studies of osteoporosis, alcohol metabolism, and lipoproteins.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-119 |
| Number of pages | 7 |
| Journal | Journal of Medical Primatology |
| Volume | 26 |
| Issue number | 3 |
| State | Published - 1997 |
| Externally published | Yes |
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Keywords
- Animal models
- Gene mapping
- Genetic epidemiology
- Multifactorial disease
ASJC Scopus subject areas
- Animal Science and Zoology
- veterinary(all)
Cite this
Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases. / VandeBerg, John L.; Williams-Blangero, Sarah.
In: Journal of Medical Primatology, Vol. 26, No. 3, 1997, p. 113-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases
AU - VandeBerg, John L.
AU - Williams-Blangero, Sarah
PY - 1997
Y1 - 1997
N2 - The genetic similarity between humans and nonhuman primates makes nonhuman primates uniquely suited as models for genetic research on complex physiological and behavioral phenotypes. By comparison with human subjects, nonhuman primates, like other animal models, have several advantages for these types of studies: 1) constant environmental conditions can be maintained over long periods of time, greatly increasing the power to detect genetic effects; 2) different environmental conditions can be imposed sequentially on individuals to characterize genotype-environment interactions; 3) complex pedigrees that are much more powerful for genetic analysis than typically available human pedigrees can be generated; 4) genetic hypotheses can be tested prospectively by selective matings; and 5) essential invasive and terminal experiments can be conducted. Limitations of genetic research with nonhuman primates include cost and availability. However, the ability to manipulate both genetic and environmental factors in captive primate populations indicates the promise of genetic research with these important animal models for illuminating complex disease processes. The utility of nonhuman primates for biomedical research on human health problems is illustrated by examples concerning the use of baboons in studies of osteoporosis, alcohol metabolism, and lipoproteins.
AB - The genetic similarity between humans and nonhuman primates makes nonhuman primates uniquely suited as models for genetic research on complex physiological and behavioral phenotypes. By comparison with human subjects, nonhuman primates, like other animal models, have several advantages for these types of studies: 1) constant environmental conditions can be maintained over long periods of time, greatly increasing the power to detect genetic effects; 2) different environmental conditions can be imposed sequentially on individuals to characterize genotype-environment interactions; 3) complex pedigrees that are much more powerful for genetic analysis than typically available human pedigrees can be generated; 4) genetic hypotheses can be tested prospectively by selective matings; and 5) essential invasive and terminal experiments can be conducted. Limitations of genetic research with nonhuman primates include cost and availability. However, the ability to manipulate both genetic and environmental factors in captive primate populations indicates the promise of genetic research with these important animal models for illuminating complex disease processes. The utility of nonhuman primates for biomedical research on human health problems is illustrated by examples concerning the use of baboons in studies of osteoporosis, alcohol metabolism, and lipoproteins.
KW - Animal models
KW - Gene mapping
KW - Genetic epidemiology
KW - Multifactorial disease
UR - http://www.scopus.com/inward/record.url?scp=0031155655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031155655&partnerID=8YFLogxK
M3 - Article
C2 - 9379477
AN - SCOPUS:0031155655
VL - 26
SP - 113
EP - 119
JO - Journal of Medical Primatology
JF - Journal of Medical Primatology
SN - 0047-2565
IS - 3
ER -