Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases

John L. VandeBerg, Sarah Williams-Blangero

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

The genetic similarity between humans and nonhuman primates makes nonhuman primates uniquely suited as models for genetic research on complex physiological and behavioral phenotypes. By comparison with human subjects, nonhuman primates, like other animal models, have several advantages for these types of studies: 1) constant environmental conditions can be maintained over long periods of time, greatly increasing the power to detect genetic effects; 2) different environmental conditions can be imposed sequentially on individuals to characterize genotype-environment interactions; 3) complex pedigrees that are much more powerful for genetic analysis than typically available human pedigrees can be generated; 4) genetic hypotheses can be tested prospectively by selective matings; and 5) essential invasive and terminal experiments can be conducted. Limitations of genetic research with nonhuman primates include cost and availability. However, the ability to manipulate both genetic and environmental factors in captive primate populations indicates the promise of genetic research with these important animal models for illuminating complex disease processes. The utility of nonhuman primates for biomedical research on human health problems is illustrated by examples concerning the use of baboons in studies of osteoporosis, alcohol metabolism, and lipoproteins.

Original languageEnglish (US)
Pages (from-to)113-119
Number of pages7
JournalJournal of Medical Primatology
Volume26
Issue number3
StatePublished - 1997
Externally publishedYes

Fingerprint

Genetic Research
Primates
Animal Models
animal models
Pedigree
pedigree
environmental factors
genotype-environment interaction
Papio
biomedical research
osteoporosis
lipoproteins
Lipoproteins
Osteoporosis
genetic techniques and protocols
human health
Biomedical Research
alcohols
Genotype
Alcohols

Keywords

  • Animal models
  • Gene mapping
  • Genetic epidemiology
  • Multifactorial disease

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

Cite this

Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases. / VandeBerg, John L.; Williams-Blangero, Sarah.

In: Journal of Medical Primatology, Vol. 26, No. 3, 1997, p. 113-119.

Research output: Contribution to journalArticle

VandeBerg, John L. ; Williams-Blangero, Sarah. / Advantages and limitations of nonhuman primates as animal models in genetic research on complex diseases. In: Journal of Medical Primatology. 1997 ; Vol. 26, No. 3. pp. 113-119.
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