Advances in endophenotyping schizophrenia

David L. Braff, Tiffany A. Greenwood, Neal R. Swerdlow, Gregory A. Light, Nicholas J. Schork, Monica E. Calkins, Raquel E. Gur, Ruben C. Gur, Bruce I. Turetsky, Dorcas J. Dobie, Allen D. Radant, Debby W. Tsuang, Robert Freedman, Ann Olincy, Kristin S. Cadenhead, Ming T. Tsuang, Michael F. Green, Jim Mintz, Keith H. Nuechterlein, Larry J. SeidmanWilliam S. Stone, Larry J. Siever, Jeremy M. Silverman

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

The search for the genetic architecture of schizophrenia has employed multiple, often converging strategies. One such strategy entails the use of tracing the heritability and neurobiology of endophenotypes. Endophenotypes are quantifiable traits not visible to the eye, which are thought to reflect an intermediate place on the path from genes to disorder. Endophenotype abnormalities in domains such as neurophysiology or neurocognition occur in schizophrenia patients as well as their clinically "unaffected" relatives, and reflect polymorphisms in the DNA of schizophrenia spectrum subjects which create vulnerability to developing schizophrenia. By identifying the single nucleotide polymorphisms (SNPs) associated with endophenotypes in schizophrenia, psychiatric neuroscientists can select new strong inference based molecular targets for the treatment of schizophrenia.

Original languageEnglish (US)
Pages (from-to)11-18
Number of pages8
JournalWorld Psychiatry
Volume7
Issue number1
DOIs
StatePublished - Feb 2008

Keywords

  • Endophenotypes
  • Neurocognition
  • Neurophysiology
  • Schizophrenia
  • Vulnerability genes

ASJC Scopus subject areas

  • Phychiatric Mental Health
  • Psychiatry and Mental health

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