Advances in antiretroviral therapy

Susan Olender, Timothy J. Wilkin, Barbara S. Taylor, Scott M. Hammer

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

The 19th Conference on Retroviruses and Opportunistic Infections (CROI) highlighted new information and provided in-depth discussion on advances in antiretroviral therapy (ART). Data regarding investigational drugs, including integrase strand transfer inhibitors (InSTIs) and zinc-finger nucleases disrupting CC chemokine receptor 5 (CCR5), were presented. Treatment trials in treatment-naive and treatment-experienced patients added to the knowledge base of which antiretroviral agents to initiate and when. Data from trials and observational cohorts suggested that, for patients on successful ART in resource-rich settings, mortality from non-HIV-related diseases may surpass that from HIV-related diseases, and overall lifespan may be nearing that of people without HIV infection. In resource-limited settings (RLS), prevention of mother-to-child transmission (PMTCT) and ART scale-up remained priorities. New data on antiretroviral resistance in RLS and on the implications of low-frequency mutations were presented.

Original languageEnglish (US)
Pages (from-to)61-86
Number of pages26
JournalTopics in Antiviral Medicine
Volume20
Issue number2
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Pharmacology
  • Virology
  • Infectious Diseases
  • Pharmacology (medical)

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    Olender, S., Wilkin, T. J., Taylor, B. S., & Hammer, S. M. (2012). Advances in antiretroviral therapy. Topics in Antiviral Medicine, 20(2), 61-86.