Advances in antiretroviral therapy

Susan Olender, Timothy J. Wilkin, Barbara Taylor, Scott M. Hammer

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The 19th Conference on Retroviruses and Opportunistic Infections (CROI) highlighted new information and provided in-depth discussion on advances in antiretroviral therapy (ART). Data regarding investigational drugs, including integrase strand transfer inhibitors (InSTIs) and zinc-finger nucleases disrupting CC chemokine receptor 5 (CCR5), were presented. Treatment trials in treatment-naive and treatment-experienced patients added to the knowledge base of which antiretroviral agents to initiate and when. Data from trials and observational cohorts suggested that, for patients on successful ART in resource-rich settings, mortality from non-HIV-related diseases may surpass that from HIV-related diseases, and overall lifespan may be nearing that of people without HIV infection. In resource-limited settings (RLS), prevention of mother-to-child transmission (PMTCT) and ART scale-up remained priorities. New data on antiretroviral resistance in RLS and on the implications of low-frequency mutations were presented.

Original languageEnglish (US)
Pages (from-to)61-86
Number of pages26
JournalTopics in antiviral medicine
Volume20
Issue number2
StatePublished - Jun 2012

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Therapeutics
CCR5 Receptors
Investigational Drugs
Anti-Retroviral Agents
Integrases
Knowledge Bases
Zinc Fingers
Mutation Rate
HIV Infections
Mothers
HIV
Mortality

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Pharmacology
  • Virology
  • Medicine(all)

Cite this

Olender, S., Wilkin, T. J., Taylor, B., & Hammer, S. M. (2012). Advances in antiretroviral therapy. Topics in antiviral medicine, 20(2), 61-86.

Advances in antiretroviral therapy. / Olender, Susan; Wilkin, Timothy J.; Taylor, Barbara; Hammer, Scott M.

In: Topics in antiviral medicine, Vol. 20, No. 2, 06.2012, p. 61-86.

Research output: Contribution to journalArticle

Olender, S, Wilkin, TJ, Taylor, B & Hammer, SM 2012, 'Advances in antiretroviral therapy', Topics in antiviral medicine, vol. 20, no. 2, pp. 61-86.
Olender S, Wilkin TJ, Taylor B, Hammer SM. Advances in antiretroviral therapy. Topics in antiviral medicine. 2012 Jun;20(2):61-86.
Olender, Susan ; Wilkin, Timothy J. ; Taylor, Barbara ; Hammer, Scott M. / Advances in antiretroviral therapy. In: Topics in antiviral medicine. 2012 ; Vol. 20, No. 2. pp. 61-86.
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