Advances and challenges in management of invasive mycoses

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Invasive mycoses pose a major diagnostic and therapeutic challenge. Advances in antifungal agents and diagnostic methods offer the potential for improved outcomes in patients with these infections, which are often lethal. Many fungal pathogens occur almost exclusively in opportunistic settings - in the immunocompromised host - and these infections are the focus of this review. Several areas of ongoing challenge remain, including the emergence of resistant organisms and the absence of reliable markers for early identification of patients at risk of developing invasive fungal disease. This Seminar reviews the changing epidemiology of invasive mycoses, new diagnostic methods, and recent therapeutic options and current management strategies for these opportunistic pathogens.

Original languageEnglish (US)
Pages (from-to)1013-1025
Number of pages13
JournalLancet
Volume366
Issue number9490
DOIs
StatePublished - Sep 17 2005

Fingerprint

Mycoses
Antifungal Agents
Immunocompromised Host
Infection
Epidemiology
Therapeutics
Invasive Fungal Infections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Advances and challenges in management of invasive mycoses. / Patterson, Thomas F.

In: Lancet, Vol. 366, No. 9490, 17.09.2005, p. 1013-1025.

Research output: Contribution to journalArticle

@article{1472b29a1f6a41fa9c3d7f445a0b1e83,
title = "Advances and challenges in management of invasive mycoses",
abstract = "Invasive mycoses pose a major diagnostic and therapeutic challenge. Advances in antifungal agents and diagnostic methods offer the potential for improved outcomes in patients with these infections, which are often lethal. Many fungal pathogens occur almost exclusively in opportunistic settings - in the immunocompromised host - and these infections are the focus of this review. Several areas of ongoing challenge remain, including the emergence of resistant organisms and the absence of reliable markers for early identification of patients at risk of developing invasive fungal disease. This Seminar reviews the changing epidemiology of invasive mycoses, new diagnostic methods, and recent therapeutic options and current management strategies for these opportunistic pathogens.",
author = "Patterson, {Thomas F}",
year = "2005",
month = "9",
day = "17",
doi = "10.1016/S0140-6736(05)67381-3",
language = "English (US)",
volume = "366",
pages = "1013--1025",
journal = "The Lancet",
issn = "0140-6736",
publisher = "Elsevier Limited",
number = "9490",

}

TY - JOUR

T1 - Advances and challenges in management of invasive mycoses

AU - Patterson, Thomas F

PY - 2005/9/17

Y1 - 2005/9/17

N2 - Invasive mycoses pose a major diagnostic and therapeutic challenge. Advances in antifungal agents and diagnostic methods offer the potential for improved outcomes in patients with these infections, which are often lethal. Many fungal pathogens occur almost exclusively in opportunistic settings - in the immunocompromised host - and these infections are the focus of this review. Several areas of ongoing challenge remain, including the emergence of resistant organisms and the absence of reliable markers for early identification of patients at risk of developing invasive fungal disease. This Seminar reviews the changing epidemiology of invasive mycoses, new diagnostic methods, and recent therapeutic options and current management strategies for these opportunistic pathogens.

AB - Invasive mycoses pose a major diagnostic and therapeutic challenge. Advances in antifungal agents and diagnostic methods offer the potential for improved outcomes in patients with these infections, which are often lethal. Many fungal pathogens occur almost exclusively in opportunistic settings - in the immunocompromised host - and these infections are the focus of this review. Several areas of ongoing challenge remain, including the emergence of resistant organisms and the absence of reliable markers for early identification of patients at risk of developing invasive fungal disease. This Seminar reviews the changing epidemiology of invasive mycoses, new diagnostic methods, and recent therapeutic options and current management strategies for these opportunistic pathogens.

UR - http://www.scopus.com/inward/record.url?scp=24944438172&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=24944438172&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(05)67381-3

DO - 10.1016/S0140-6736(05)67381-3

M3 - Article

C2 - 16168784

AN - SCOPUS:24944438172

VL - 366

SP - 1013

EP - 1025

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 9490

ER -