Advancements and challenges in the management of pneumonia in elderly patients with COPD

Sebastian Ocrospoma; Antonio Anzueto; Marcos I. Restrepo

doi:10.1080/17476348.2024.2422961

Advancements and challenges in the management of pneumonia in elderly patients with COPD

Sebastian Ocrospoma, Antonio Anzueto, Marcos I. Restrepo

Division of Pulmonary Diseases

Research output: Contribution to journal › Review article › peer-review

Abstract

Introduction: Chronic Obstructive Pulmonary Disease (COPD) significantly predisposes the elderly to pneumonia, presenting a complex interplay of pulmonary dysfunction and infection risk. Areas covered: This article reviews the substantial epidemiologic impact, elucidates the interlinked pathophysiology of COPD and pneumonia, and examines the microbial landscape shaping infection in these patients. It also evaluates management protocols and the multifaceted clinical challenges encountered during treatment. Expert opinion: Delving into the latest research, we underscore the criticality of preventive measures such as vaccination and present an integrated approach to managing Community-Acquired Pneumonia (CAP) in the COPD demographic. The review also proposes strategic directions for future investigations aimed at enhancing patient outcomes through a deeper understanding of the COPD-pneumonia nexus.

Original language	English (US)
Pages (from-to)	975-989
Number of pages	15
Journal	Expert Review of Respiratory Medicine
Volume	18
Issue number	12
DOIs	https://doi.org/10.1080/17476348.2024.2422961
State	Published - 2024

Keywords

COPD
Pneumonia
aged
antibacterial agents
elderly
frailty
microbiology

ASJC Scopus subject areas

Immunology and Allergy
Pulmonary and Respiratory Medicine
Public Health, Environmental and Occupational Health

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10.1080/17476348.2024.2422961

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title = "Advancements and challenges in the management of pneumonia in elderly patients with COPD",

abstract = "Introduction: Chronic Obstructive Pulmonary Disease (COPD) significantly predisposes the elderly to pneumonia, presenting a complex interplay of pulmonary dysfunction and infection risk. Areas covered: This article reviews the substantial epidemiologic impact, elucidates the interlinked pathophysiology of COPD and pneumonia, and examines the microbial landscape shaping infection in these patients. It also evaluates management protocols and the multifaceted clinical challenges encountered during treatment. Expert opinion: Delving into the latest research, we underscore the criticality of preventive measures such as vaccination and present an integrated approach to managing Community-Acquired Pneumonia (CAP) in the COPD demographic. The review also proposes strategic directions for future investigations aimed at enhancing patient outcomes through a deeper understanding of the COPD-pneumonia nexus.",

keywords = "COPD, Pneumonia, aged, antibacterial agents, elderly, frailty, microbiology",

author = "Sebastian Ocrospoma and Antonio Anzueto and Restrepo, {Marcos I.}",

note = "Publisher Copyright: {\textcopyright} This work was authored as part of the Contributor{\textquoteright}s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.",

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doi = "10.1080/17476348.2024.2422961",

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AU - Ocrospoma, Sebastian

AU - Anzueto, Antonio

AU - Restrepo, Marcos I.

N1 - Publisher Copyright: © This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

PY - 2024

Y1 - 2024

N2 - Introduction: Chronic Obstructive Pulmonary Disease (COPD) significantly predisposes the elderly to pneumonia, presenting a complex interplay of pulmonary dysfunction and infection risk. Areas covered: This article reviews the substantial epidemiologic impact, elucidates the interlinked pathophysiology of COPD and pneumonia, and examines the microbial landscape shaping infection in these patients. It also evaluates management protocols and the multifaceted clinical challenges encountered during treatment. Expert opinion: Delving into the latest research, we underscore the criticality of preventive measures such as vaccination and present an integrated approach to managing Community-Acquired Pneumonia (CAP) in the COPD demographic. The review also proposes strategic directions for future investigations aimed at enhancing patient outcomes through a deeper understanding of the COPD-pneumonia nexus.

AB - Introduction: Chronic Obstructive Pulmonary Disease (COPD) significantly predisposes the elderly to pneumonia, presenting a complex interplay of pulmonary dysfunction and infection risk. Areas covered: This article reviews the substantial epidemiologic impact, elucidates the interlinked pathophysiology of COPD and pneumonia, and examines the microbial landscape shaping infection in these patients. It also evaluates management protocols and the multifaceted clinical challenges encountered during treatment. Expert opinion: Delving into the latest research, we underscore the criticality of preventive measures such as vaccination and present an integrated approach to managing Community-Acquired Pneumonia (CAP) in the COPD demographic. The review also proposes strategic directions for future investigations aimed at enhancing patient outcomes through a deeper understanding of the COPD-pneumonia nexus.

KW - COPD

KW - Pneumonia

KW - aged

KW - antibacterial agents

KW - elderly

KW - frailty

KW - microbiology

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Advancements and challenges in the management of pneumonia in elderly patients with COPD

Abstract

Keywords

ASJC Scopus subject areas

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