Advanced cancer patients understanding and perceptions of phase i clinical trials

Jamie Pawlowski, Laeeq Malik, Devalingam Mahalingam

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This questionnaire-based study assessed the understanding and perceptions of cancer patients who were participating in a Phase I clinical trial at baseline and determined any changes after enrollment. Thirty-six patients participated. Less than one-third of respondents (28.5%) thought the purpose of Phase I trials was dose escalation for safety and efficacy. Patients anticipated varying degree of therapeutic benefit ranging from stable disease (47.1%) to complete shrinkage of the tumor (32.4%). No change in measured themes was observed. Patients participating in Phase I trials need further education to improve their understanding of the true intent of early Phase trials.

Original languageEnglish (US)
Pages (from-to)490-495
Number of pages6
JournalCancer Investigation
Issue number10
StatePublished - Nov 26 2015


  • Chemotherapy
  • Clinical trials
  • Medical ethics

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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