Adult svz lineage cells home to and leave the vascular niche via differential responses to SDF1/CXCR4 signaling

Erzsebet Kokovay, Susan Goderie, Yue Wang, Steve Lotz, Gang Lin, Yu Sun, Badrinath Roysam, Qin Shen, Sally Temple

Research output: Contribution to journalArticlepeer-review

269 Scopus citations

Abstract

Neural progenitor cells (NPCs) in the adult subventricular zone (SVZ) are associated with ependymal and vasculature niches, which regulate stem cell self-renewal and differentiation. Activated Type B stem cells and their progeny, the transit-amplifying type C cells, which express EGFR, are most highly associated with vascular cells, indicating that this niche supports lineage progression. Here, we show that proliferative SVZ progenitor cells home to endothelial cells in a stromal-derived factor 1 (SDF1)- and CXC chemokine receptor 4 (CXCR4)-dependent manner. We show that SDF1 strongly upregulates EGFR and α6 integrin in activated type B and type C cells, enhancing their activated state and their ability to bind laminin in the vascular niche. SDF1 increases the motility of type A neuroblasts, which migrate from the SVZ toward the olfactory bulb. Thus, differential responses to SDF1 can regulate progenitor cell occupancy of and exit from the adult SVZ vascular niche.

Original languageEnglish (US)
Pages (from-to)163-173
Number of pages11
JournalCell Stem Cell
Volume7
Issue number2
DOIs
StatePublished - Aug 6 2010

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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