Adriamycin and cis‐platinum administered by continuous infusion preoperatively in hepatoblastoma unresectable at presentation

A. M. Langevin, A. Pierro, P. Liu, R. M. Filler, M. L. Greenberg

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Hepatoblastoma deemed surgically unresectable at presentation is fatal unless conversion to resectability is attained. We report a series of six consecutive patients, ranging in age from newborn to 5.75 years with hepatoblastoma unresectable at presentation, either because of size of tumor or its anatomical boundaries, or because of metastatic disease. All were treated with preoperative continuous infusions of cis‐platinum and Adriamycin. All achieved resect‐ability, and there was only one operative death. The five surviving patients are alive and free of disease off therapy. Potential benefit may accrue from preoperative chemotherapy in most cases of hepatoblastoma.

Original languageEnglish (US)
Pages (from-to)181-184
Number of pages4
JournalMedical and Pediatric Oncology
Volume18
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • liver tumors
  • neoadjuvant chemotherapy
  • surgical resection

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Oncology
  • Cancer Research

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