Adrenopause

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The senescent decline of the production of dehydroepiandrosterone and its sulfate (DHEA(S)) by the human adrenal cortex is referred to as adrenopause. As an age-related biological phenomenon, it presents special challenges for appropriate modeling because it is only known to occur in humans. Rodents generally do not synthesize these steroids and primates that have human-like adrenal glands are often not ideal for use in biomedical research. The hypothesis put forward here is that the creation of a humanized mouse model could be very valuable in modeling and understanding adrenopause. Two types of humanized mouse models are proposed: genetically modified mice that faithfully mimic human adrenal steroidogenesis and immunodeficient mice with transplanted human adrenal organoids that synthesize DHEA(S). Significant challenges exist with respect to both forms of humanized mouse models for adrenopause.

Original languageEnglish (US)
Title of host publicationConn's Handbook of Models for Human Aging
PublisherElsevier
Pages131-137
Number of pages7
ISBN (Electronic)9780128113530
DOIs
StatePublished - Jan 1 2018

Keywords

  • Adrenal cortex
  • Adrenopause
  • Dehydroepiandrosterone
  • Mouse models
  • Organoids
  • Pluripotent stem cells
  • Primates
  • Zona reticularis

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Hornsby, P. J. (2018). Adrenopause. In Conn's Handbook of Models for Human Aging (pp. 131-137). Elsevier. https://doi.org/10.1016/B978-0-12-811353-0.00010-5