Adrenergic receptors in rat spinal cord

D. J. Jones, D. E. Kendall, S. J. Enna

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Radioligand binding assays were used to demonstrate the presence of α1, α(2) and β receptora in rat spinal cord. Specific and saturable binding was exhibited for [3H-WB 4101 (α1), [3H]-aminoclonldine (α2) and [3H]-dihydroalprenolol(β). Binding was of high affinity and the total number of binding sites (Bmaxwere: α1, 66.5 ± 1.0 fmol/mg protein; α2, 20.0 ± 0.6 fmol/mg protein; β, 10.2 ± 0.3 fmol/mg protein. The data confirms the existence of adrenergic receptors in spinal cord and provides further evidence of the role of catecholaminergic neurons in regulating spinal cord physiology.

Original languageEnglish (US)
Pages (from-to)191-195
Number of pages5
JournalNeuropharmacology
Volume21
Issue number2
DOIs
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

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    Jones, D. J., Kendall, D. E., & Enna, S. J. (1982). Adrenergic receptors in rat spinal cord. Neuropharmacology, 21(2), 191-195. https://doi.org/10.1016/0028-3908(82)90162-9