Adrenergic component of renin release induced by vasodilating antihypertensive drugs in the rat

W. A. Pettinger, W. B. Campbell, K. Keeton

Research output: Contribution to journalArticlepeer-review

89 Scopus citations

Abstract

The capacity of the vasodilating drugs, minoxidil and hydralazine, for inducing renin release was characterized in rats according to chronology and dose response. Propranolol inhibition of this renin release was also characterized and related to serum levels of propranolol. Minoxidil and hydralazine (1.0 mg/kg) induced sevenfold elevations of serum renin activity. Treatment with propranolol, resulting in plasma propranolol concentrations as low as 50 ng/ml, impaired vasodilatory drug induced renin release. The propranolol inhibition suggests a beta adrenergic component to this type of renin release and the potential for a clinically efficacious drug interaction.

Original languageEnglish (US)
Pages (from-to)82-86
Number of pages5
JournalCirculation research
Volume33
Issue number1
DOIs
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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